PYC Therapeutics (PYC) investor relations material

Executive summary

• Focused on providing transparency into upcoming human data readouts across four pipeline programs, including a deep dive into the PKD program as it approaches a critical 18-month window for transition to registrational studies.

• Developing RNA therapies for diseases caused by insufficient gene expression, targeting major unmet medical needs, with a pipeline including clinical-stage candidates for PKD, Phelan-McDermid Syndrome, Autosomal Dominant Optic Atrophy, and Retinitis Pigmentosa Type 11.

• Organizational build-out continues with new executive hires and U.S. team expansion in clinical, legal, and financial roles to support late-stage clinical development and commercialization.

• Multiple human safety and efficacy readouts are expected within the next 18 months, with continuous data generation through 2027.

Financial highlights

• Recent capital raising in February has provided sufficient funding to independently progress assets through clinical development.

• No direct financial results or explicit ratios disclosed, but significant investment in organizational expansion and clinical development, with operational runway and balance sheet strength highlighted.

• Increased share turnover attributed to heightened investor interest, proximity to efficacy readouts, and an upcoming index rebalance.

Outlook and guidance

• Anticipates key clinical milestones, including single-dose and multiple-dose safety and efficacy data for PKD, with primary registrational readouts expected by the end of 2027 and progression to registrational studies for key programs anticipated in 2028.

• Plans to bring a fourth drug candidate into the clinic next year and expand the preclinical pipeline.

• Ongoing preparations for potential dual listing on NASDAQ, with Sarbanes-Oxley compliance groundwork underway.