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Rigel Pharmaceuticals (RIGL) investor relations material
Rigel Pharmaceuticals H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Business strategy and product portfolio
Focus on expanding hematology and oncology business with three commercial products: TAVALISSE, Rezlidia, and Gavreto.
Rezlidia and Gavreto were acquired to diversify and grow the portfolio, with ongoing interest in further in-licensing and acquisitions.
TAVALISSE is indicated for chronic ITP, Rezlidia for relapsed/refractory IDH1-positive AML, and Gavreto for RET fusion-positive cancers.
Strategic partnerships and collaborations are being pursued to maximize product reach and development opportunities.
Commercial performance and market opportunities
Achieved 76% year-over-year net product sales growth, with $102.5 million in sales through Q2 2025, matching 2023's full-year total.
TAVALISSE has moved from late-line to earlier-line use in ITP, with higher response rates in earlier lines.
Rezlidia and Gavreto are showing strong growth, with Gavreto's Q2 net revenues rising to $11.8 million.
International collaborations are expanding product availability and contributing to revenue growth.
Research and development pipeline
IRAC-1/4 dual inhibitor (R289) in phase 1B for lower-risk MDS, with promising safety and efficacy data and FDA fast-track and orphan designations.
Dose escalation phase for R289 completed, with dose expansion phase and further data presentations planned by year-end.
Luticidinib (Rezlidia) is being explored for glioma through collaborations and potential internal studies.
Strategic collaborations with MD Anderson and CONNECT are advancing IDH1-related research.
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