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Visual22 Oct 2025
Epiroc's cash spent on M&A
Sagimet Biosciences (SGMT) investor relations material
Sagimet Biosciences H.C. Wainwright Liver Disease Virtual Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright Liver Disease Virtual Conference summary21 Oct, 2025
Scientific focus and differentiation
Developing FASN inhibitors targeting metabolic and fibrotic pathways in diseases like MASH, acne, and certain tumors.
Denifanstat is the only late-stage fat synthesis inhibitor in clinical development, showing significant fibrosis improvement in severe MASH patients.
Combination of denifanstat with resmetirom shows amplified response in MASH markers; phase I PK study underway with results expected in the first half of next year.
Partner Ascletis in China reported statistically significant phase III results in moderate to severe acne; NMPA submission planned.
Mechanism of action and clinical data
FASN inhibition targets fat accumulation, inflammation, and fibrosis in three liver cell types, offering a unique direct effect on stellate cells.
Denifanstat met primary and secondary endpoints in phase II-B FASCINATE-2 trial, showing significant improvements in fibrosis and MASH resolution.
Digital AI pathology and traditional pathology both confirm significant fibrosis improvement, especially in advanced disease (F3/F4 patients).
36% delta over placebo for one-stage fibrosis improvement and 30% for two-stage improvement in F3 patients.
Regulatory and technology landscape
Digital pathology is gaining regulatory acceptance, especially for advanced fibrosis; non-invasive measures like VCTE and FAST score are becoming important endpoints.
FDA has accepted FibroScan technology as a robust surrogate for drug response, aligning clinical practice with regulatory approval.
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Next Sagimet Biosciences earnings date
Guggenheim Securities 2nd Annual Healthcare Innovation Conference10 Nov, 2025
Next Sagimet Biosciences earnings date
Guggenheim Securities 2nd Annual Healthcare Innovation Conference10 Nov, 2025
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Frequently asked questions
Sagimet Biosciences Inc., previously known as 3-V Biosciences, Inc., is a clinical-stage biopharmaceutical company. It focuses on developing innovative therapeutics called fatty acid synthase (FASN) inhibitors. These inhibitors target diseases caused by the overproduction of the fatty acid, palmitate, including non-alcoholic steatohepatitis (NASH), acne, and various forms of cancer. Sagimet Biosciences' expertise in fatty acid synthase allows it to pioneer treatments for these diseases by targeting dysfunctional metabolic pathways. Its lead product candidate, denifanstat, is an oral, once-daily selective FASN inhibitor, currently being evaluated in clinical trials for patients with NASH. The company was incorporated in 2006 and is headquartered in San Mateo, California, USA. Its shares are listed on the Nasdaq.
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