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Investor Relations14 Oct 2025
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Sana Biotechnology (SANA) investor relations material
Sana Biotechnology H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary9 Sep, 2025
Business overview and platforms
Focus on two foundational platforms: HypoImmune for immune evasion and Fusogen for cell-specific in vivo delivery.
Main discussion centered on type 1 diabetes, with updates on allogeneic and in vivo CAR-T programs.
HypoImmune Platform and clinical data
HypoImmune Platform disrupts MHC class I/II and overexpresses CD47 to evade both adaptive and innate immunity.
Proof of concept in type 1 diabetes published in The New England Journal of Medicine, showing successful immune evasion and insulin production in a patient after 30 years.
Six-month data showed stable C-peptide and no safety events, meeting all study endpoints.
Imaging confirmed survival of transplanted islet cells at the injection site.
Immune assays demonstrated that HypoImmune-edited cells were not targeted by T cells, antibodies, or natural killer cells.
Pipeline progress and future plans
IND filing for SC451, a stem cell-derived HypoImmune islet therapy for type 1 diabetes, expected as early as next year.
Ongoing phase 1 trials for SC291 (CD19-directed CAR-T for autoimmune diseases) and SC262 (CD22-directed CAR-T for relapsed/refractory NHL), with data expected in 2025.
Fusogen Platform enables cell-specific in vivo delivery of genetic material, with lead candidate SG299 targeting B cell diseases; IND filing anticipated in 2026.
Impact of master cell bank for SC451
Target patient population for SC262 CAR-T?
How does SG299 avoid off-target effects?
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Next Sana Biotechnology earnings date
Q3 202511 Nov, 2025
Next Sana Biotechnology earnings date
Q3 202511 Nov, 2025
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Frequently asked questions
Sana Biotechnology Inc. is a biotechnology company focusing on the development of engineered cells as medicines. The company focuses on both ex vivo and in vivo cell engineering platforms to address a variety of therapeutic areas with significant unmet needs, including oncology, diabetes, central nervous system disorders, and autoimmune diseases among others. Sana Biotechnology's approach involves the use of cutting-edge technologies such as CRISPR for gene editing and their proprietary platforms, Fusogen for in vivo cell engineering, and a hyperimmune platform for ex vivo cell engineering. They are actively investigating potential treatments for conditions such as non-Hodgkin lymphoma, acute lymphoblastic leukemia, chronic lymphocytic leukemia, multiple myeloma, and diabetes, to name a few. The company is headquartered in Seattle, Washington, and its shares are listed on the NASDAQ.
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