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Sangamo Therapeutics (SGMO) investor relations material
Sangamo Therapeutics Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary6 Nov, 2025
Executive summary
Advanced clinical and preclinical pipeline in Fabry disease, chronic neuropathic pain, and prion disease, with first neurology clinical study patient recruitment and enrollment.
Fabry disease program (ST-920) achieved positive registrational data, with durable kidney and cardiac outcomes, and is on a clear path to potential accelerated approval.
Productive regulatory interactions with FDA and MHRA for Fabry and prion disease programs, with FDA reaffirming eGFR slope as endpoint.
Neurology pipeline includes ST-503 (chronic neuropathic pain, Phase 1/2 trial initiated) and ST-506 (prion disease, CTA submission expected mid-2026).
Ongoing business development efforts to secure Fabry commercialization partner and advance industry partnerships.
Financial highlights
Q3 2025 net loss of $34.9 million, or $0.11 per share; nine-month net loss of $85.5 million.
Revenues for Q3 2025 were $0.6 million, down sharply from $49.4 million in Q3 2024, mainly due to prior year Genentech collaboration revenue.
Cash and cash equivalents as of September 30, 2025: $29.6 million, with $6 million from Pfizer and $9.1 million from at-the-market offering received after quarter-end.
Non-GAAP operating expenses for Q3 2025 were $33.0 million; GAAP OpEx was $36.1 million.
Up to $5.9 billion in potential future milestones and exercise fees from partnerships.
Outlook and guidance
Cash runway expected to fund operations into Q1 2026, including recent Pfizer license fee and stock sale proceeds, but additional capital is required.
Preparing for a BLA submission for Fabry disease gene therapy as early as Q1 2026, contingent on funding and regulatory agreement.
Prion disease CTA submission expected as early as mid-2026; preliminary clinical data for neurology programs anticipated from early 2027.
2025 GAAP operating expenses expected to be $135–$155 million; non-GAAP OpEx expected at $125–$145 million.
Actively seeking new capital through equity, debt, and strategic collaborations.
Fabry BD: What's the next key milestone?
ST-503: What efficacy signal defines success?
STAC-BBB: How does success unlock neurology?
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Next Sangamo Therapeutics earnings date
Q4 202519 Mar, 2026
Next Sangamo Therapeutics earnings date
Q4 202519 Mar, 2026
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Frequently asked questions
Sangamo Therapeutics, Inc. is a clinical-stage biotechnology company, which engages in therapeutic genome editing. The company's lead program is focused on treating inherited blood disorder beta-thalassemia and sickle cell disease by ex vivo genome editing in hematopoietic stem and progenitor cells from adult patients. It is also focusing on genome editing for HIV/AIDS; hemophilia; Huntington's disease; LCA6; other rare and infectious diseases; cancer and degenerative conditions. Sangamo Therapeutics, Inc. was incorporated in 1995 and is headquartered in Brisbane, California.
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