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Senti Biosciences
Senti Biosciences (SNTI) investor relations material
Senti Biosciences TD Cowen 46th Annual Health Care Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.TD Cowen 46th Annual Health Care Conference summary2 Mar, 2026
Key technology and therapeutic approach
Logic-gated cell therapies selectively kill cancer cells while sparing healthy cells, addressing a major challenge in oncology treatment.
SENTI-202 is an off-the-shelf allogeneic NK cell therapy targeting CD33 and FLT3, covering over 95% of AML patients.
The therapy uses an activating CAR for cancer targets, an inhibitory CAR for healthy cells, and IL-15 to enhance NK activity.
Logic-gating technology is adaptable to both NK and T cells and is being explored for solid tumors.
SENTI-202 is not genetically restricted, allowing broad patient eligibility.
Clinical data and outcomes
In a phase I study with relapsed/refractory AML patients, SENTI-202 achieved a 50% overall response rate and 42% CR/CRh at RP2D, with a 7.6-month median duration of CRs.
100% of CRs were MRD negative, indicating deep responses and potential for improved patient outcomes.
The safety profile was favorable, with most adverse events related to lymphodepletion and manageable; no significant CRS observed.
Responses were observed across patients with adverse genetic features and those refractory to prior therapies.
Outpatient dosing is feasible, and the product is suitable for rapid delivery due to its off-the-shelf nature.
Mechanism of action and differentiation
SENTI-202's logic gate design enables selective killing of AML blasts and leukemic stem cells while sparing healthy hematopoietic stem cells.
CyTOF analysis confirmed maintenance or increase of healthy stem cells in responders, supporting the logic gate's function.
The therapy is effective even in patients with high-risk genetics, including complex karyotypes.
The approach is differentiated from existing therapies by not requiring specific genetic mutations and by targeting both AML blasts and stem cells.
The technology is being adapted for solid tumors, with proof-of-concept shown for CEA-positive cancers using a NOT gate to protect healthy cells.
SENTI-202's broad eligibility vs. targeted AML?
Frontline AML: Venetoclax combo strategy?
Rationale for Flu-Ara-C lymphodepletion in AML?
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Next Senti Biosciences earnings date
Leerink Global Healthcare Conference 20269 Mar, 2026
Senti Biosciences
Next Senti Biosciences earnings date
Leerink Global Healthcare Conference 20269 Mar, 2026
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Frequently asked questions
Senti Biosciences Inc. is a biotechnology company engaged in developing innovative cell and gene therapies. The company specializes in the use of gene circuit technologies, which involve designing and programming cells to function as intelligent medicines capable of addressing various diseases. Senti Biosciences’ platform focuses on three main areas: off-the-shelf CAR-NK cells for oncology, gene therapies targeting specific tissues, and cell therapies for regenerative medicine. Their lead product candidates include therapies targeting different types of cancer using CAR-NK cells engineered with these gene circuits. Senti Biosciences is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.
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