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Senti Biosciences (SNTI) investor relations material
Senti Biosciences Chardan’s 9th Annual Genetic Medicines Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Chardan’s 9th Annual Genetic Medicines Conference summary21 Oct, 2025
Program overview and technology
Lead program SENTI-202 uses logic gate technology to target cancer cells while sparing healthy cells, addressing the lack of unique cancer-specific targets in many cancers.
Logic gates are engineered into NK and T cells, enabling applications in both liquid and solid tumors.
SENTI-202 is an off-the-shelf allogeneic CAR NK cell therapy targeting CD33 or FLT3 in AML, with a NOT gate for EMCN to protect healthy cells.
The product received orphan drug designation and showed positive preliminary efficacy data at AACR in April.
Additional phase I data is expected before year-end, with potential for pivotal studies and expansion into solid tumors.
Clinical study design and patient population
Ongoing phase I multicenter, multinational study in relapsed/refractory AML, focusing on adults with CD33 or FLT3 positivity and prior treatments.
Dose escalation explored two dose levels (1B and 1.5B cells) and two schedules, with lymphodepletion using fludarabine and ARSC.
Patients are high-risk, often primary refractory, with prior exposure to multiple therapies and adverse risk by ELN 2022.
Safety profile is favorable, with no SAEs or DLTs attributable to SENTI-202; main adverse events relate to lymphodepletion.
Dose level two, schedule one, selected as RP2D; FDA concurred on potential outpatient administration.
Efficacy and mechanistic data
Five of seven evaluable patients achieved ORR, including full CR, CR with partial hematologic recovery, or MLFS; four achieved MRD-negative status.
Significant reduction in bone marrow blast counts observed, with durability of responses ranging from four to eight-plus months.
CyTOF analysis confirmed LSC killing in all CR/composite CR patients, with over tenfold decrease in LSCs.
Platelet and neutrophil counts recovered within 14–21 days post-lymphodepletion; healthy progenitor cells maintained or increased.
Multi-cycle dosing is feasible, with product detectable in patients for about two weeks per cycle.
SENTY-202 MRD-neg rates vs. approved AML drugs?
What is the solid tumor strategy for logic gates?
Impact of outpatient administration on SENTY-202?
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Next Senti Biosciences earnings date
Q3 202513 Nov, 2025
Next Senti Biosciences earnings date
Q3 202513 Nov, 2025
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Frequently asked questions
Senti Biosciences Inc. is a biotechnology company engaged in developing innovative cell and gene therapies. The company specializes in the use of gene circuit technologies, which involve designing and programming cells to function as intelligent medicines capable of addressing various diseases. Senti Biosciences’ platform focuses on three main areas: off-the-shelf CAR-NK cells for oncology, gene therapies targeting specific tissues, and cell therapies for regenerative medicine. Their lead product candidates include therapies targeting different types of cancer using CAR-NK cells engineered with these gene circuits. Senti Biosciences is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.
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