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Seres Therapeutics (MCRB) investor relations material
Seres Therapeutics Q3 2026 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Q3 revenue was $593K and net loss was $16.286M; cash and cash equivalents were $17.528M at Sept. 30, 2026.
SER-155 allo-HCT Phase 2 remains paused pending funding, while planning continues for an irEC prevention study and earlier-stage programs.
In an investigator-sponsored SER-155 irEC trial, 12 of 15 participants (80%) achieved an immunosuppressive-free diarrhea response by Day 15; no drug-related serious adverse events were observed.
Financial highlights
Q3 2026 revenue was $593K vs. $351K YoY, all from CARB-X grant revenue; nine-month revenue was $1.687M vs. $351K.
Q3 operating expenses were $16.745M vs. $22.828M YoY; nine-month expenses were $60.019M vs. $74.945M. Q3 R&D and G&A expenses were $5.6M and $5.4M, respectively.
Q3 net loss was $16.286M vs. net income of $8.204M YoY; nine-month net loss was $31.618M vs. net income of $21.031M.
Q3 2025 results included a $27.222M VOWST business gain; nine-month 2026 results included the $25M VOWST milestone termination gain.
Nine-month cash used in operations was $49.231M; investing cash inflow was $12.566M and financing cash inflow was $2.895M. Cash, equivalents and restricted cash ended at $20.664M.
Outlook and guidance
Available cash, including the $12.5M VOWST milestone termination payment received in October, is expected to fund operations through Q1 2027; additional funding is expected to be required thereafter.
SER-155 allo-HCT Phase 2 remains paused pending funding; the planned study is expected to enroll ~248 participants and include an interim analysis.
FDA submission of the SER-155 irEC prophylaxis study design is expected in Q1 2027, with dose optimization and evaluation in patients initiating ICI therapy; development is funding-dependent.
SER-428 IND readiness is targeted by end-2026; further development depends on grants or other funding. SER-603 remains in preclinical development with IND-enabling work ongoing.
R&D and G&A expenses were expected to decrease in 2026 vs. 2025 following workforce reductions, TSA completion and lower program and facilities spending.
- Showcased microbiome therapies with strong clinical data and plans for strategic partnerships.MCRB
H.C. Wainwright 28th Annual Global Investment Conference - Up to $300M in securities, including $100M ATM equity, to fund clinical pipeline and operations.MCRB
Registration filing - Q2 2026 profit from VOWST milestone and SER-155 success, but urgent funding needed by Q1 2027.MCRB
Q2 2026 - All proposals passed, including director elections and incentive plan amendment; no questions submitted.MCRB
AGM 2026 - SER-155 achieved 80% immunosuppressive-free response in irEC with strong safety and biomarker support.MCRB
Study result - SER-155 delivers 77% risk reduction in bloodstream infections, driving pipeline momentum.MCRB
Company presentation - AI-driven microbiome therapeutics pipeline advances toward key clinical and commercial milestones.MCRB
H.C. Wainwright 4th Annual BioConnect Investor Conference - Q1 2026 net loss of $19.9M, $29.8M cash, runway through Q3, and urgent need for new funding.MCRB
Q1 2026 - Leadership changes and SER-155 data in Q2 2026, with cash runway through Q3 2026.MCRB
Status update
Next Seres Therapeutics earnings date
Next Seres Therapeutics earnings date
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