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SOPHiA GENETICS (SOPH) investor relations material
SOPHiA GENETICS Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary5 Aug, 2025
Executive summary
Q2 2025 revenue grew 16% year-over-year to $18.3M, driven by new business, advanced applications, and strong global expansion.
Signed a record 35 new customers in Q2, totaling 63 new customers year-to-date, and implemented 18 new customers during the quarter.
Announced the largest contract in company history: a multi-year AI partnership with AstraZeneca focused on breast cancer predictive modeling and real-world evidence.
Cash burn reduced to $8.7M, a 35% year-over-year improvement, and adjusted gross margin rose to 74.4%.
AI-powered platform analyzed over 350,000 patients in 2024, serving 800+ institutions in 70+ countries.
Financial highlights
Q2 2025 revenue was $18.3M, up from $15.8M in Q2 2024, with 16% year-over-year growth.
Adjusted gross margin reached 74.4% in Q2 2025, up 120bps year-over-year.
Adjusted EBITDA loss expected between $35M and $39M in 2025, improving from $40.2M in 2024.
Cash and equivalents at quarter-end were $94.8M, bolstered by a $35M debt drawdown.
Platform analysis volume reached 95,000 in Q2 2025, up 9% year-over-year.
Outlook and guidance
Reaffirmed full-year 2025 revenue guidance of $72M–$76M (10%–17% growth) and adjusted EBITDA loss guidance of $35M–$39M.
Q4 expected to be the strongest quarter; AstraZeneca revenue recognition to begin in Q4 and continue into 2026.
Targeting adjusted EBITDA breakeven by 2026 and positive adjusted EBITDA in 2027.
Adjusted gross margin anticipated to expand slightly in 2025.
Approximately 60% of incremental revenue expected to flow through to EBITDA.
AZ deal: What are the specific deliverables?
What is the strategy for reaching EBITDA breakeven?
How are MSK-ACCESS implementation times improving?
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Next SOPHiA GENETICS earnings date
Q3 20254 Nov, 2025
Next SOPHiA GENETICS earnings date
Q3 20254 Nov, 2025
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Frequently asked questions
SOPHiA GENETICS SA is a health technology company that provides a cloud-based analytics platform for data-driven medicine. Its solutions support genomic and radiomic data interpretation for clinical and research purposes, primarily in oncology, hereditary disorders, and infectious diseases. The company serves hospitals, laboratories, and pharmaceutical companies. It is headquartered in Saint-Sulpice, Switzerland, and its shares are listed on the NASDAQ.
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