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SOPHiA GENETICS (SOPH) investor relations material
SOPHiA GENETICS Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary4 Nov, 2025
Executive summary
Q3 2025 revenue grew 23% year-over-year to $19.5 million, marking the third consecutive quarter of accelerating growth.
31 new customers signed in Q3, bringing the 2025 total to 94, with average contract value up 180% year-over-year.
Major expansion and strategic partnerships were secured with top institutions and companies including AstraZeneca, Memorial Sloan Kettering, Myriad Genetics, and Adam Innovations.
Liquid biopsy application MSK Access now has over 60 customers globally, with adoption ramping up.
AI-powered platform analyzed over 350,000 patients in 2024, serving 800+ institutions in 70+ countries.
Financial highlights
Q3 2025 revenue was $19.5 million, up 23% year-over-year; constant currency growth was 18%.
Adjusted gross margin held at 73.1% for Q3 2025; reported gross margin was 66.3%.
Adjusted EBITDA loss was $10.2 million in Q3, up 8% year-over-year; full-year loss expected between $39–41 million, reflecting currency and social charges.
Cash and cash equivalents stood at $81.6 million as of September 30, 2025.
Net dollar retention was 108% in Q3 2025, with annualized revenue churn at 4%.
Outlook and guidance
Full-year 2025 revenue guidance raised to $75–$77 million, representing 15–18% growth.
Adjusted EBITDA loss guidance revised to $39–$41 million, reflecting currency impacts and social taxes.
Company expects to approach adjusted EBITDA break-even by end of 2026 and achieve positive adjusted EBITDA in H2 2027.
Adjusted gross margin expected to expand slightly in 2025.
Continued investment in platform and commercial teams expected to support growth into 2026 and beyond.
MSK Access revenue ramp from signed customers?
OpEx strategy for 2026 EBITDA break-even?
Biopharma partnerships' strategic platform impact?
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Next SOPHiA GENETICS earnings date
Q4 20253 Mar, 2026
Next SOPHiA GENETICS earnings date
Q4 20253 Mar, 2026
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Frequently asked questions
SOPHiA GENETICS SA is a health technology company that provides a cloud-based analytics platform for data-driven medicine. Its solutions support genomic and radiomic data interpretation for clinical and research purposes, primarily in oncology, hereditary disorders, and infectious diseases. The company serves hospitals, laboratories, and pharmaceutical companies. It is headquartered in Saint-Sulpice, Switzerland, and its shares are listed on the NASDAQ.
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