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SOPHiA GENETICS (SOPH) investor relations material
SOPHiA GENETICS Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary4 Nov, 2025
Executive summary
Q3 2025 revenue grew 23% year-over-year to $19.5M, marking the third consecutive quarter of accelerating growth.
Raised full-year 2025 revenue guidance to $75M–$77M, reflecting strong business momentum and robust pipeline.
Signed 31 new customers in Q3, bringing the 2025 total to 94, with average contract value up 180% year-over-year.
Expanded presence at major institutions and saw strong adoption of new applications, especially in liquid biopsy and US market.
Strategic partnerships with Memorial Sloan Kettering, AstraZeneca, and others expanded offerings in liquid biopsy and solid tumors.
Financial highlights
Q3 2025 revenue was $19.5M, up from $15.9M in Q3 2024, a 23% increase; constant currency growth was 18%.
Adjusted gross margin held at 73.1% in Q3 2025, flat year-over-year, with reported gross margin at 66.3%.
Adjusted EBITDA loss was $10.2M in Q3 2025, up 8% year-over-year; full-year loss expected at $39M–$41M.
Cash and equivalents stood at $81.6M at quarter-end; Q3 cash burn was $13.1M, and operating cash outflow for the first nine months was $27.6M.
Platform analysis volume reached 99,000 in Q3 2025, up 9% year-over-year.
Outlook and guidance
Full-year 2025 revenue guidance raised to $75M–$77M (15–18% growth), up from $72M–$76M.
Adjusted EBITDA loss guidance revised to $39M–$41M, reflecting currency impacts and social taxes.
Targeting adjusted EBITDA break-even by end of 2026 and positive adjusted EBITDA in H2 2027.
Expecting continued operating leverage and modest gross margin expansion.
Approximately 60% of incremental revenue is expected to flow through to EBITDA.
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Next SOPHiA GENETICS earnings date
Q4 20253 Mar, 2026
Next SOPHiA GENETICS earnings date
Q4 20253 Mar, 2026
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Frequently asked questions
SOPHiA GENETICS SA is a health technology company that provides a cloud-based analytics platform for data-driven medicine. Its solutions support genomic and radiomic data interpretation for clinical and research purposes, primarily in oncology, hereditary disorders, and infectious diseases. The company serves hospitals, laboratories, and pharmaceutical companies. It is headquartered in Saint-Sulpice, Switzerland, and its shares are listed on the NASDAQ.
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