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Spero Therapeutics (SPRO) investor relations material
Spero Therapeutics Registration filing summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Company overview and business model
Clinical-stage biopharmaceutical company focused on next-generation medicines for immune-mediated diseases.
Lead program, SP001, is a fully humanized monoclonal antibody targeting CD40 Ligand, licensed from Innovent Biologics and Fortvita Biologics for global development (excluding certain Asian territories).
Developing SP001 for Immunoglobulin G4 related disease, with potential for broader immune-mediated indications.
Financial performance and metrics
As of June 30, 2026, 58,146,910 shares of common stock outstanding; pro forma up to 140,791,538 shares if full offering is completed at $1.21/share.
Historical net tangible book value as of June 30, 2026: $44.2 million ($0.76/share); pro forma net tangible book value after offering: $141.1 million ($1.00/share).
Immediate dilution to new investors estimated at $0.21/share if offering is completed at $1.21/share.
Use of proceeds and capital allocation
Net proceeds intended for general corporate purposes, including clinical trials, R&D, working capital, capital expenditures, investments, acquisitions, and collaborations.
Management retains broad discretion over allocation of proceeds.
- FDA approval, $105M financing, and SP001 focus extend cash runway into 2029.SPRO
Q2 2026 - SP001 advances as a differentiated, potent therapy for IgG4-RD and Sjögren's disease.SPRO
Company presentation - All AGM proposals, including director elections and share increase, were approved by shareholders.SPRO
AGM 2026 - Net loss narrowed, cash runway extends to 2028, and tebipenem HBr awaits FDA decision.SPRO
Q1 2026 - Stockholders will vote on director elections, auditor ratification, compensation, share increase, and new incentives.SPRO
Proxy filing - Key votes include director elections, auditor ratification, and doubling authorized shares.SPRO
Proxy filing - Stockholders will vote on director elections, auditor ratification, compensation, share increase, and new incentives.SPRO
Proxy filing - Returned to profitability in 2025, driven by collaboration revenue and milestone payments.SPRO
Q4 2025 - Q2 net loss widened to $17.9M as R&D spending rose; cash runway extends into late 2025.SPRO
Q2 2024
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