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Supernus Pharmaceuticals (SUPN) investor relations material
Supernus Pharmaceuticals Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary17 Nov, 2025
Business overview and growth drivers
Revenue guidance for the year is $685 million to $705 million, supported by a diversified CNS-focused portfolio.
Four main growth products: Qelbree (ADHD), Gocovri (Parkinson's), Onapgo (Parkinson's), and Zurzuvae (postpartum depression).
Qelbree is annualizing at $320 million in sales, with about 1% market share and patent protection until 2035.
Onapgo demand has exceeded expectations, with initial peak sales guidance of $200–$300 million potentially being conservative.
Zurzuvae is the only oral treatment for postpartum depression, acquired via Sage Therapeutics, with sales milestones structured in the acquisition.
Business development and financial strategy
Business development remains a priority, with a clean balance sheet and $300 million in cash post-acquisition.
Willing to pursue transactions in the $1–1.5 billion range, using equity if necessary, while maintaining leverage at 2–2.5x EBITDA.
Focus is on acquiring commercial or late-stage assets, especially in CNS, psychiatry, neurology, movement disorders, and now women's health.
Open to expanding in women's health due to new OB-GYN sales force.
Onapgo supply and market dynamics
Onapgo supply constrained due to fill/finish production line limitations, not API or device issues.
New patient initiations paused to prioritize current patients; working with European partners to resolve supply.
Exploring additional suppliers and long-term solutions to minimize 2026 impact.
Orphan drug exclusivity pending FDA confirmation; product is a drug-device combo with complex regulatory pathway.
Differentiated from competitors by being a potent dopamine agonist, not Levodopa.
ONAPGO supply resolution strategy and timeline
ZURZUVAE market acceleration drivers for 2026
BD focus to fill 2027-2030 launch pipeline gap
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Next Supernus Pharmaceuticals earnings date
Piper Sandler 37th Annual Healthcare Conference2 Dec, 2025
Next Supernus Pharmaceuticals earnings date
Piper Sandler 37th Annual Healthcare Conference2 Dec, 2025
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Frequently asked questions
Supernus Pharmaceuticals Inc. is a biopharmaceutical company focused on the development and commercialization of treatments for central nervous system (CNS) disorders. The company specializes in therapies for neurological and psychiatric conditions, including epilepsy, attention deficit hyperactivity disorder (ADHD), and depression. Supernus Pharmaceuticals Inc. is headquartered in Rockville, Maryland, and its shares are listed on the NASDAQ.
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