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Surrozen (SRZN) investor relations material
Surrozen H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary10 Sep, 2025
Scientific innovation and platform overview
Focus on bispecific antibodies targeting the Wnt pathway, previously considered undruggable, for large ophthalmology patient populations.
Broad intellectual property portfolio with issued patents and 37 patent applications, supporting leadership in Wnt biology.
Published 17 manuscripts across various disease areas and tissue types, demonstrating scientific depth.
Ability to target different Frizzled receptors, enabling disease-specific antibody design.
Pipeline and clinical development
Lead molecule outlicensed to Boehringer Ingelheim, expected to enter the clinic in 2024 or 2025.
Internal lead candidates SCN-8141 and SCN-8143 combine Wnt activation with VEGF and IL-6 inhibition for broader efficacy.
First in-house clinical trial targeted for 2026, with potential for rapid progression based on competitor timelines.
Preclinical data show normalization of retinal vessels and restoration of tight junctions, suggesting superior outcomes to current therapies.
Competitive landscape and strategic activity
Merck acquired a direct competitor for up to $3 billion after clinical proof-of-concept in diabetic macular edema.
Roche expected to enter the field, having acquired related compounds.
Outlicensing agreement with Boehringer Ingelheim is narrow, allowing continued development of related molecules.
How do bispecifics improve on Wnt-only therapies?
Detail IP strategy against Wnt pathway competitors
How does BI's earlier entry impact Surrozen's plan?
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Q3 20254 Nov, 2025
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Frequently asked questions
Surrozen Inc., established in 2015, is a clinical-stage biotechnology firm at the forefront of developing novel therapeutics designed to selectively modulate the Wnt pathway for tissue repair and regeneration. The company's innovative approach involves the creation of targeted regenerative antibodies intended to repair a wide array of tissues and restore organ function damaged by serious diseases. Surrozen leverages advanced antibody engineering techniques and a deep understanding of Wnt pathway biology across various disease settings to design tissue-specific antibodies. These antibodies have the potential to regenerate tissue in a multitude of organs and tissues, addressing diseases such as liver, intestine, retinal, lacrimal gland, lung, cornea, pancreas, skin, and many others. The company is headquartered in South San Francisco, California, and its shares are listed on the Nasdaq.
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