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Sutro Biopharma
Sutro Biopharma (STRO) investor relations material
Sutro Biopharma 44th Annual J.P. Morgan Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.44th Annual J.P. Morgan Healthcare Conference summary15 Jan, 2026
Strategic transformation and leadership
Underwent a strategic pivot in 2024, redefining strategy, right-sizing the team, and accelerating the pipeline.
New leadership team with deep ADC experience and a focus on execution and discipline.
Reduced team and expenses by two-thirds to streamline operations and focus resources.
Cash runway extends to at least mid-2027, not including potential collaboration milestones.
Actively seeking partnerships to advance programs and manage resource constraints.
ADC pipeline and technology differentiation
Advancing a differentiated pipeline of single- and dual-payload ADCs, with three INDs planned over the next three years.
Lead candidates STRO-004, STRO-006, and STRO-227, with initial clinical data and IND submissions expected between mid-2026 and 2027.
Proprietary cell-free platform enables precise control of payload ratios, high-throughput antibody screening, and incorporation of non-natural amino acids for stability and safety.
Optimized linker and antibody design reduces off-target toxicity and improves safety profile.
Dual payload ADCs engineered to overcome resistance, deliver targeted chemo combinations, and set new standards of care.
Clinical and preclinical program highlights
STRO-004 (TF-targeting ADC) in phase I, showing robust anti-tumor activity and high safety window, with Phase 1 data expected mid-2026.
STRO-006 (ITGB6-targeting ADC) demonstrates superior selectivity and anti-tumor activity, with IND filing planned for 2026.
STRO-227 (PTK7 dual-payload ADC) aims to overcome resistance and improve outcomes, with IND submission anticipated in 2026-2027.
Dual payload ADCs demonstrate superior activity in models resistant to single payloads, with well-tolerated dosing at 25 mg/kg.
Collaboration with Astellas on iADC program, combining immunostimulatory and cytotoxic payloads, entering clinic in 2024 or early 2026.
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Next Sutro Biopharma earnings date
Q4 202527 Mar, 2026
Sutro Biopharma
Next Sutro Biopharma earnings date
Q4 202527 Mar, 2026
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Frequently asked questions
Sutro Biopharma Inc. is a biotechnology company specializing in the discovery, development, and manufacturing of therapeutics aimed at treating cancer. The company leverages its proprietary cell-free protein synthesis platform, XpressCF, to design and produce novel, targeted antibody-drug conjugates (ADCs), bispecific antibodies, and other protein therapeutics. Sutro's focus is on creating therapies that precisely target and eliminate cancer cells while minimizing damage to healthy tissues, advancing treatment options for patients with difficult-to-treat cancers. The company is headquartered in San Francisco, California, and its shares are listed on the NASDAQ.
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