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Synlogic (SYBX) investor relations material
Synlogic Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary7 Aug, 2025
Executive summary
Discontinued lead Phase 3 trial (Synpheny-3) for PKU in February 2024 after internal review indicated unlikely success; strategic alternatives including merger or sale are being actively pursued.
Corporate restructuring reduced workforce to one full-time employee, with consultants supporting ongoing operations and strategic review.
No product revenue generated; focus remains on maximizing shareholder value through potential transactions.
Financial highlights
Net loss of $0.5 million for Q2 2025, compared to net income of $3.1 million in Q2 2024; net loss of $0.2 million for the six months ended June 30, 2025, versus $22.5 million loss in the prior year period.
Research and development expenses dropped to $0.01 million in Q2 2025 from $2.2 million in Q2 2024, reflecting the discontinued trial and restructuring.
General and administrative expenses decreased to $0.8 million in Q2 2025 from $1.2 million in Q2 2024 due to lower headcount and professional fees.
Restructuring and other charges were a gain of $0.01 million in Q2 2025, compared to a $3.8 million gain in Q2 2024, mainly from asset sales and lease termination.
Cash and cash equivalents were $17.0 million as of June 30, 2025, down from $19.8 million at year-end 2024.
Outlook and guidance
Current cash and cash equivalents expected to fund operations at current levels for at least the next 12 months.
Expenses anticipated to remain low in the near term as the company continues to evaluate strategic alternatives.
No expectation of product revenue unless regulatory approval is achieved or a strategic transaction is completed.
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Q3 202511 Nov, 2025
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Frequently asked questions
Synlogic Inc. is a biotechnology company focused on developing synthetic biotic medicines, which are engineered living organisms designed to treat metabolic and other diseases. The company’s platform uses genetically modified bacteria to deliver therapeutic effects within the human body, targeting diseases such as phenylketonuria (PKU) and other metabolic disorders. Synlogic’s approach aims to address unmet medical needs through innovative treatments that leverage the power of synthetic biology. The company is headquartered in Cambridge, Massachusetts, and its shares are listed on the NASDAQ.
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