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Synlogic (SYBX) investor relations material
Synlogic Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary13 Nov, 2025
Executive summary
Discontinued lead Phase 3 clinical trial (Synpheny-3 for PKU) in February 2024 after internal review indicated it was unlikely to meet its primary endpoint; no safety concerns cited.
Corporate restructuring initiated, reducing workforce to one full-time employee and engaging consultants to support strategic review and business operations.
Current strategy is focused on pursuing strategic alternatives, including a potential merger, sale, or partnerships.
Financial highlights
Net loss of $2.3 million for Q3 2025, compared to $0.1 million in Q3 2024; net loss of $2.5 million for the nine months ended September 30, 2025, versus $22.6 million for the same period in 2024.
Operating expenses for Q3 2025: $0.01 million in R&D, $0.8 million in G&A, $0.2 million in restructuring; significant reductions from prior year.
Cash and cash equivalents of $15.6 million as of September 30, 2025, down from $19.8 million at year-end 2024.
Accumulated deficit of $444.2 million as of September 30, 2025.
Outlook and guidance
Current cash and cash equivalents expected to fund operations at current levels for at least the next 12 months from the filing date.
Expenses anticipated to remain stable in the near term as the company continues to evaluate strategic alternatives.
Prioritized strategic transaction types?
Cash runway if strategic alternatives fail?
Preclinical pipeline status with one employee?
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Q4 202516 Mar, 2026
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Frequently asked questions
Synlogic Inc. is a biotechnology company focused on developing synthetic biotic medicines, which are engineered living organisms designed to treat metabolic and other diseases. The company’s platform uses genetically modified bacteria to deliver therapeutic effects within the human body, targeting diseases such as phenylketonuria (PKU) and other metabolic disorders. Synlogic’s approach aims to address unmet medical needs through innovative treatments that leverage the power of synthetic biology. The company is headquartered in Cambridge, Massachusetts, and its shares are listed on the NASDAQ.
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