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Tango Therapeutics (TNGX) investor relations material
Tango Therapeutics Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler 37th Annual Healthcare Conference summary3 Dec, 2025
Clinical program updates
Three clinical programs are prioritized for 2026: Vopimetostat, TNG456, and TNG260.
Vopimetostat shows a 27% overall response rate and 6.4 months median PFS, outperforming a key competitor.
In second-line pancreatic cancer, Vopimetostat achieved a 25% response rate and 7.2 months median PFS, doubling standard chemotherapy outcomes.
Histology-selective cohort saw a 49% response rate and over 9 months median PFS, supporting single-agent activity.
TNG456 targets GBM with brain penetration, and TNG260 is advancing in STK11-mutant, KRAS wild-type NSCLC.
Competitive landscape and differentiation
Vopimetostat demonstrates superior target engagement and safety profile versus BMS-504, with less GI toxicity and rash.
Only PRMT5 inhibitor combined with KRAS inhibitors in partnership with Revolution Medicines.
Competitors like Amgen, AstraZeneca, and ZEON are behind in development; BMS focuses on first-line, not second-line, pancreatic cancer.
FDA alignment achieved for pivotal study design, with a 250 mg dose selected.
Clinical trial design and strategy
Pivotal phase III in second-line pancreatic cancer will randomize Vopimetostat vs. four standard chemotherapy regimens.
Hierarchical design allows for initial PFS readout, then overall survival if positive.
Study start targeted for 2026, with FDA design alignment and focus on rapid execution.
Companion diagnostic uses IHC for faster, more sensitive MTAP deletion detection.
Bopametastat's market strategy given KRASi approval
Combination therapy's role in front-line strategy
TNG456: GBM approval strategy
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Next Tango Therapeutics earnings date
44th Annual J.P. Morgan Healthcare Conference14 Jan, 2026
Next Tango Therapeutics earnings date
44th Annual J.P. Morgan Healthcare Conference14 Jan, 2026
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Frequently asked questions
Tango Therapeutics Inc. is a biotechnology firm focused on the discovery and development of innovative treatments for cancer. The company's research is centered on creating drugs that target specific genetic vulnerabilities in cancer cells. One of its leading projects, TNG908, is a synthetic lethal small molecule inhibitor designed for treating cancers characterized by methylthioadenosine phosphorylase deletions. Additionally, Tango Therapeutics is developing several other compounds, including TNG462 for similar indications, TNG260 targeting repressor element-1 silencing transcription, TNG348 aimed at BRCA1 or BRCA2-mutant cancers, and another compound targeting STK11-mutant cancers. The company is based in Boston, Massachusetts and its shares are listed on the Nasdaq.
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