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Taysha Gene Therapies (TSHA) investor relations material
Taysha Gene Therapies Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary12 Aug, 2025
Executive summary
Achieved FDA and Health Canada alignment on pivotal trial design for TSHA-102 in Rett syndrome, with site activation commenced and patient enrollment expected in Q4 2025; Part A of REVEAL trials showed all evaluable patients gained or regained at least one developmental milestone, with high dose patients achieving milestones faster and no treatment-related serious adverse events or dose-limiting toxicities in 12 patients as of August 2025.
Raised $230M in a follow-on offering in May 2025, extending cash runway into 2028; refinanced debt to $50M with improved terms, and cash and equivalents totaled $312.8M as of June 30, 2025.
Financial highlights
R&D expenses were $20.1M for Q2 2025, up from $15.1M in Q2 2024, driven by manufacturing, clinical trial activities, and increased headcount.
G&A expenses rose to $8.6M from $7.3M year-over-year, mainly due to higher legal and professional fees.
Net loss for Q2 2025 was $26.9M ($0.09/share) versus $20.9M ($0.09/share) in Q2 2024; weighted average shares outstanding increased to 297.99M in Q2 2025 from 232.82M in Q2 2024.
Cash and equivalents totaled $312.8M as of June 30, 2025.
Outlook and guidance
Current cash resources expected to fund operations into 2028; additional capital will be needed for future development, manufacturing, and commercialization activities.
Patient enrollment for the pivotal trial to begin in Q4 2025; new supplemental Part A data to be reported in Q4 2025.
Ongoing regulatory engagement in the US, Canada, and Europe, with a scientific advice meeting scheduled in Europe for early fall.
What is the FDA's current stance on 6-month interim BLA?
What new Part A data will be shared in Q4?
What is the plan for building commercial inventory?
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Next Taysha Gene Therapies earnings date
Q3 202512 Nov, 2025
Next Taysha Gene Therapies earnings date
Q3 202512 Nov, 2025
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Frequently asked questions
Taysha Gene Therapies Inc. is a biotechnology company focused on developing gene therapies for the treatment of monogenic diseases of the central nervous system. The company leverages its adeno-associated virus (AAV) gene therapy platform to create treatments targeting rare genetic disorders, particularly those affecting the brain and spinal cord. Taysha's pipeline includes therapies aimed at conditions such as neurodegenerative and neurodevelopmental diseases, with a mission to provide life-changing treatments for patients with limited or no therapeutic options. The company is advancing its programs through research, clinical development, and regulatory processes. The company is headquartered in Dallas, Texas, and its shares are listed on the NASDAQ.
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