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Teva Pharmaceutical Industries (TEVA) investor relations material

Teva Pharmaceutical Industries Study Update summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Study Update summary29 Sep, 2025

Study design and context

  • Ongoing phase IIa trial of atabinib plus modified gemcitabine and nab-paclitaxel in first-line pancreatic cancer patients, with a data cutoff of August 26, 2025.

  • 34 patients enrolled, median age 69, with a significant proportion having liver metastases.

  • Study population is older than those in pivotal studies for standard of care, with similar distribution of metastases.

  • No genetic testing required for enrollment, allowing for a broad patient population.

  • Study funded through 2029 following a $175M underwritten offering and $25M private placement, including strategic investment from Sanofi.

Efficacy results

  • Six-month overall survival (OS) was 94%, and nine-month OS was 86%, nearly double the benchmark for standard of care.

  • Median overall survival not yet reached due to a flat survival curve.

  • Progression-free survival (PFS) at six months was 70%, and at nine months was 53%, with a median PFS of 9.6 months.

  • Strong separation in OS and PFS compared to all three standard of care regimens, including gemcitabine+nab-paclitaxel, FOLFIRINOX, and NALIRIFOX.

  • Subgroup analysis showed identical PFS for patients with liver metastases as the overall population.

Robustness and supporting endpoints

  • Results supported by 95% confidence intervals, with even the lower bound showing significant separation from standard of care.

  • Surrogate endpoints (overall response rate 39%, disease control rate 81%) also favor atabinib over benchmarks.

  • Waterfall and spider plots show most patients have shrinking lesions, with slow, durable responses.

  • Lower rate of censoring than typical for oncology studies, further supporting data robustness.

  • Efficacy observed in both older and younger, higher fitness patients, and in those with liver metastases.

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Frequently asked questions

Teva Pharmaceutical Industries Limited, a pharmaceutical company, develops, manufactures, markets and distributes generic medicines and a portfolio of specialty medicines worldwide. It operates in two segments, Generic Medicines and Specialty Medicines. The company offers various APIs and molecules for the treatment of various disorders in a range of therapeutic areas, including CNS, oncology, respiratory, cardiology and other specialty areas. The company was founded in 1901 and is headquartered in Tel Aviv-Yafo, Israel.

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