TG Therapeutics
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TG Therapeutics (TGTX) investor relations material

TG Therapeutics 44th Annual J.P. Morgan Healthcare Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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44th Annual J.P. Morgan Healthcare Conference summary13 Jan, 2026

Strategic focus and market overview

  • Focused on B-cell mediated diseases, primarily multiple sclerosis (MS), with Briumvi as the lead product.

  • Briumvi is approved globally, available in 16 countries, and has over 20,000 patients treated, mostly in the U.S.

  • Competes in the anti-CD20 market, which represents about $10 billion in sales and 50% of the MS dynamic market share.

  • Over 97% of top 200 MS centers use Briumvi, which holds about 20% dynamic share in the HCP-administered anti-CD20 segment.

  • Aims to become the number one prescribed anti-CD20 for relapsing MS based on dynamic market share.

Financial performance and guidance

  • Surpassed $1 billion in cumulative net sales, with $616 million in global revenue and $594 million in U.S. net revenue for the latest year.

  • Achieved 90% year-over-year growth and outperformed quarterly targets.

  • 2026 global net revenue guidance is $875–$900 million, with $825–$850 million expected from the U.S.

  • Core operating expenses targeted at $350 million, with additional one-time costs for subcu Briumvi inventory and manufacturing.

  • Significant cash flow and EBITDA expected, with potential for increased share repurchases and accelerating profitability.

Product differentiation and commercial strategy

  • Briumvi offers a one-hour infusion every six months, with consistent efficacy and safety over six years.

  • Lacks breast cancer and colitis risks, and is glycoengineered for enhanced ADCC.

  • Priced as the lowest branded MS treatment, facilitating rapid payer coverage and broad access.

  • Won the VA contract, offering the lowest price for veterans in the U.S.

  • Customer service and experienced MS-focused team drive adoption and ease of onboarding.

How will SubQ BRIUMVI capture patient-admin share?
Prioritize non-MS BRIUMVI vs Azer-cel trials
Expected return on $100M one-time OpEx?
Detail the proprietary HCP targeting algorithm
Explain subcu BRIUMVI's non-cannibalizing growth
Azer-cel: What defines a 'win scenario' in PPMS?
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Q4 202527 Feb, 2026
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Frequently asked questions

TG Therapeutics, Inc., a commercial stage biopharmaceutical company, focuses on the acquisition, development, and commercialization of novel treatments for B-cell malignancies and autoimmune diseases. The company's therapeutic product candidates include Ublituximab, an investigational glycoengineered monoclonal antibody for the treatment of B-cell non-hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL), and relapsing forms of multiple sclerosis; Umbralisib, an oral inhibitor of PI3K delta and CK1 epsilon for the treatment of CLL and follicular lymphoma; Cosibelimab, a human monoclonal antibody that binds to programmed death ligand 1 (PD-L1) and blocks its interactions with PD-1 and B7.1 receptors; TG-1701 is an orally available Bruton's tyrosine kinase (BTK) inhibitor that exhibits selectivity to BTK over ibrutinib in in vitro kinase screening; TG-1801, a bispecific CD47/CD19 antibody generated by fusion technology platform across two distinct proteins each comprising single chain moieties from humanized IgG.

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