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Travere Therapeutics (TVTX) investor relations material
Travere Therapeutics Corporate Presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Strategic vision and market opportunity
Focus on rare kidney and metabolic diseases with three potential treatment standards and a global market projected to exceed $10B.
Addressable patient populations: >70,000 for IgAN, up to 30,000 for FSGS in the U.S., and 7,000–10,000 for HCU globally.
Continued pipeline diversification through external innovation and expertise in rare disease therapy development.
Product pipeline and regulatory milestones
FILSPARI (sparsentan) fully approved for IgAN in the U.S. and under review for FSGS, with a PDUFA target date of January 13, 2026.
Pegtibatinase in development as a potential first disease-modifying therapy for classical HCU; Phase 3 HARMONY Study enrollment to restart in 2026.
Global commercial partnerships established for FILSPARI, with launches in Europe and Asia and up to $910M in potential milestone payments.
FILSPARI in IgA nephropathy (IgAN)
FILSPARI is the only non-immunosuppressive, oral, once-daily therapy proven to significantly slow kidney function decline in IgAN.
Demonstrated ~50% proteinuria reduction at 36 weeks and ~40% at 2 years in Phase 3 studies, with safety comparable to irbesartan.
Commercial launch outperformed benchmarks, with $72M U.S. net sales in 2Q25 and high patient access and prescriber adoption.
Positioned as foundational care in IgAN, supported by evolving KDIGO guidelines recommending earlier intervention.
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