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TScan Therapeutics (TCRX) investor relations material
TScan Therapeutics H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary10 Sep, 2025
Key clinical program updates
Lead heme malignancy program showed an 8% relapse rate in treated patients versus 33% in controls, prompting advancement to a pivotal trial this year.
Updated phase one data and longer-term follow-up will be presented at a major medical conference at year-end.
Pivotal trial will use TSC-101, with a synthetic control arm from the CIBMTR database, aiming for top-line data by end of 2027.
Expansion to additional HLA types is underway, with two new TCRs in IND-enabling activities and more in discovery.
$218 million in cash provides runway into Q1 2027.
Clinical data and safety
Phase one study included 26 treated and 12 control patients, with balanced high-risk profiles between arms.
Treatment was well tolerated, with no increase in adverse events compared to controls; only mild, manageable CRS observed.
Treated patients showed higher rates of complete donor chimerism and sustained MRD negativity post-infusion.
Substantial reduction in relapse rates observed, supporting progression to pivotal trial.
Market opportunity and expansion
Initial addressable market is ~1,300 patients/year in the US and Europe, with potential to expand to over 5,000 as clinical practice shifts.
Expansion to additional HLA types could double the market, with further opportunities to reach over 15,000 patients annually.
Pivotal trial: FDA view on synthetic control arm?
How to drive haploidentical donor market shift?
How will multiplex therapy overcome heterogeneity?
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Next TScan Therapeutics earnings date
Q3 202511 Nov, 2025
Next TScan Therapeutics earnings date
Q3 202511 Nov, 2025
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Frequently asked questions
TScan Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing T cell receptor-engineered T cell (TCR-T) therapies to treat cancer. The company's lead candidates, TSC-100 and TSC-101, target hematologic malignancies like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) to eliminate residual disease and prevent relapse following allogeneic hematopoietic cell transplantation. Additionally, TScan is advancing a pipeline of multiplexed TCR-T therapies for solid tumors, supported by its proprietary ImmunoBank, which houses a diverse collection of therapeutic TCRs. The company is headquartered in Waltham, Massachusetts, and its shares are listed on the NASDAQ.
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