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TScan Therapeutics (TCRX) investor relations material

TScan Therapeutics H.C. Wainwright 27th Annual Global Investment Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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H.C. Wainwright 27th Annual Global Investment Conference summary10 Sep, 2025

Key clinical program updates

  • Lead heme malignancy program showed an 8% relapse rate in treated patients versus 33% in controls, prompting advancement to a pivotal trial this year.

  • Updated phase one data and longer-term follow-up will be presented at a major medical conference at year-end.

  • Pivotal trial will use TSC-101, with a synthetic control arm from the CIBMTR database, aiming for top-line data by end of 2027.

  • Expansion to additional HLA types is underway, with two new TCRs in IND-enabling activities and more in discovery.

  • $218 million in cash provides runway into Q1 2027.

Clinical data and safety

  • Phase one study included 26 treated and 12 control patients, with balanced high-risk profiles between arms.

  • Treatment was well tolerated, with no increase in adverse events compared to controls; only mild, manageable CRS observed.

  • Treated patients showed higher rates of complete donor chimerism and sustained MRD negativity post-infusion.

  • Substantial reduction in relapse rates observed, supporting progression to pivotal trial.

Market opportunity and expansion

  • Initial addressable market is ~1,300 patients/year in the US and Europe, with potential to expand to over 5,000 as clinical practice shifts.

  • Expansion to additional HLA types could double the market, with further opportunities to reach over 15,000 patients annually.

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Frequently asked questions

TScan Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing T cell receptor-engineered T cell (TCR-T) therapies to treat cancer. The company's lead candidates, TSC-100 and TSC-101, target hematologic malignancies like acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) to eliminate residual disease and prevent relapse following allogeneic hematopoietic cell transplantation. Additionally, TScan is advancing a pipeline of multiplexed TCR-T therapies for solid tumors, supported by its proprietary ImmunoBank, which houses a diverse collection of therapeutic TCRs. The company is headquartered in Waltham, Massachusetts, and its shares are listed on the NASDAQ.

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