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United Therapeutics (UTHR) investor relations material

United Therapeutics UBS Global Healthcare Conference 2025 summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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UBS Global Healthcare Conference 2025 summary10 Nov, 2025

Financial and operational highlights

  • Achieved double-digit year-over-year growth in the Tyvaso franchise, driven by continued expansion in PH-ILD and strong adoption of both DPI and nebulizer formats.

  • Noted no material impact from new competitors, with market expansion attributed to increased awareness and diagnosis.

  • Expressed confidence in reaching a $4 billion revenue run rate by the end of 2027, supported by recent clinical trial clarity.

  • Higher-dose Tyvaso cartridges (80, 96, 112 mcg) to launch soon, enhancing patient convenience and supporting those on higher doses.

  • No active partnership discussions currently, but open to future collaborations to support global market expansion.

Clinical development and pipeline updates

  • TETON-2 trial for IPF delivered best-ever data for the indication, with strong efficacy and safety; TETON-1 results expected by mid-2026.

  • Discontinuation rates in TETON-2 were in line with previous IPF trials, with efficacy accumulating after titration to effective dose.

  • Ralinepag advanced outcomes trial is powered for six-minute walk distance and PVR endpoints, with data expected in the first half of 2026.

  • Ralinepag offers once-daily, titratable dosing, aiming for differentiation from competitors.

Xenotransplantation program

  • First clinical IND kidney transplant using a 10-gene edited organ completed, marking a major milestone.

  • Study structured in two cohorts: initial six patients, followed by a review and potential expansion to 44+ patients.

  • Next public update expected after completion of the first cohort; timelines remain uncertain due to study complexity.

  • Platform differentiation includes targeted gene edits and a long history of R&D investment; market size allows for multiple successful players.

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Jefferies London Healthcare Conference 202518 Nov, 2025
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Frequently asked questions

United Therapeutics Corporation is a biotechnology company specializing in the development and commercialization of therapies to address chronic and life-threatening conditions. The company focuses on treatments for pulmonary arterial hypertension (PAH) and other cardiovascular and respiratory diseases. Its portfolio includes pharmaceutical products and delivery systems designed to improve patient outcomes and quality of life. The company is headquartered in Silver Spring, Maryland, and its shares are listed on the NASDAQ Stock Exchange.

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