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United Therapeutics (UTHR) investor relations material
United Therapeutics Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary18 Nov, 2025
Commercial business performance and outlook
Tyvaso and Tyvaso DPI are key growth drivers, with strong uptake in PH-ILD and positive prescriber and patient feedback.
No dosing limitations and favorable payer dynamics support Tyvaso DPI's continued growth.
Despite new competition from Yutrepia, referral and start trends are returning to pre-launch levels, indicating resilience.
Market expansion is expected as more therapies increase awareness and diagnosis, growing the addressable patient population.
A $1 billion quarterly revenue run rate is targeted by end of 2027, mainly from current commercial products, with pipeline contributions expected later.
Competitive landscape and litigation
New entrants like Yutrepia and WINREVAIR are seen as expanding the market rather than eroding share.
Ongoing litigation with Yutrepia is not expected to impact growth, as Tyvaso DPI continues to post strong results.
Confidence remains high in the commercial portfolio regardless of litigation outcomes.
Pipeline and clinical development
TETON 2 data for IPF showed significant FVC benefit and strong safety, with a large commercial opportunity in a 100,000-patient U.S. market.
High conviction that TETON 2 results will translate to TETON 1; both trials are required for FDA approval, with TETON 1 unblinding expected in H1 2026.
PPF represents another sizable opportunity, with optimism for similar success as in IPF.
Ralinepag, a once-daily oral therapy for PAH, is expected to read out in H1 2026 and could offer higher efficacy and compliance benefits.
Development of a once-daily inhaled treprostinil is ongoing, with more details to be shared after key trial readouts.
Tyvaso DPI growth drivers post-Yutrepia launch
IPF filing strategy: TETON 1 translation & pooling
Organ transplant program: Next steps & data cadence
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Next United Therapeutics earnings date
Q4 202526 Feb, 2026
Next United Therapeutics earnings date
Q4 202526 Feb, 2026
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Frequently asked questions
United Therapeutics Corporation is a biotechnology company specializing in the development and commercialization of therapies to address chronic and life-threatening conditions. The company focuses on treatments for pulmonary arterial hypertension (PAH) and other cardiovascular and respiratory diseases. Its portfolio includes pharmaceutical products and delivery systems designed to improve patient outcomes and quality of life. The company is headquartered in Silver Spring, Maryland, and its shares are listed on the NASDAQ Stock Exchange.
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