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Visual22 Oct 2025
Epiroc's cash spent on M&A
Upstream Bio (UPB) investor relations material
Upstream Bio Stifel Virtual Immunology and Inflammation Forum summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Stifel Virtual Immunology and Inflammation Forum summary15 Sep, 2025
Company overview and strategy
Developing Viraqita, a potent TSLP receptor antagonist, with unique pharmacology allowing for extended dosing intervals of 12 or 24 weeks.
Advancing Viraqita in three indications: chronic rhinosinusitis with nasal polyps, severe asthma, and COPD, all in phase 2 trials.
Substantial funding secured through a recent IPO, supporting operations and trials through 2027.
Planning phase 3 investments and preparing material and device for commercialization.
Scientific and clinical differentiation
Viraqita targets the TSLP receptor, unlike competitors that target the ligand, resulting in unique pharmacology and high potency.
Demonstrated full occupancy of TSLP receptors for up to 24 weeks after dosing, supporting infrequent administration.
Blocking the receptor is believed to have a more significant effect on TSLP signaling than ligand targeting.
Chronic rhinosinusitis with nasal polyps (CRSwNP) program
CRSwNP is less prevalent but highly burdensome, often requiring surgery and systemic steroids.
High overlap exists between CRSwNP and severe asthma, with many patients affected by both.
Phase 2 trial designed per FDA guidance, using robust endpoints and a placebo-controlled approach.
Efficacy endpoints include endoscopic nasal polyp score and nasal congestion score.
Viraqita's unique TSLP receptor targeting advantage?
Market impact of Viraqita's q12-week dosing?
CRSwNP data's read-through to q24-week asthma dosing?
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Next Upstream Bio earnings date
Q3 20256 Nov, 2025
Next Upstream Bio earnings date
Q3 20256 Nov, 2025
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Frequently asked questions
Upstream Bio Inc. is a U.S.-based biotechnology company focused on developing innovative therapies for inflammatory and allergic diseases. The company’s research is centered on targeting key biological pathways involved in immune response, with the goal of creating treatments that address unmet medical needs in conditions such as asthma and other chronic inflammatory disorders. Upstream Bio’s pipeline includes investigational drugs aimed at modulating immune mechanisms to improve patient outcomes and quality of life. Upstream Bio Inc. is headquartered in Waltham, Massachusetts.
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