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Upstream Bio (UPB) investor relations material
Upstream Bio Stifel Virtual Immunology and Inflammation Forum summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Company overview and strategy
Developing Viraqita, a potent TSLP receptor antagonist, with unique pharmacology allowing for extended dosing intervals of 12 or 24 weeks.
Advancing Viraqita in three indications: chronic rhinosinusitis with nasal polyps, severe asthma, and COPD, all in phase 2 trials.
Substantial funding secured through a recent IPO, supporting operations and trials through 2027.
Planning phase 3 investments and preparing material and device for commercialization.
Scientific and clinical differentiation
Viraqita targets the TSLP receptor, unlike competitors that target the ligand, resulting in unique pharmacology and high potency.
Demonstrated full occupancy of TSLP receptors for up to 24 weeks after dosing, supporting infrequent administration.
Blocking the receptor is believed to have a more significant effect on TSLP signaling than ligand targeting.
Chronic rhinosinusitis with nasal polyps (CRSwNP) program
CRSwNP is less prevalent but highly burdensome, often requiring surgery and systemic steroids.
High overlap exists between CRSwNP and severe asthma, with many patients affected by both.
Phase 2 trial designed per FDA guidance, using robust endpoints and a placebo-controlled approach.
Efficacy endpoints include endoscopic nasal polyp score and nasal congestion score.
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