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Vertex Pharmaceuticals (VRTX) investor relations material
Vertex Pharmaceuticals Bank of America Global Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Bank of America Global Healthcare Conference 2025 summary23 Sep, 2025
Key catalysts and pipeline updates
Three ongoing commercial launches: LifTrak for cystic fibrosis, Casgevy for sickle cell disease and beta thalassemia, and Jurnavix for acute pain, marking a new phase of revenue and commercialization diversification.
Four ongoing phase 3 programs and a fifth to start soon, including diabetic peripheral neuropathy, immunoglobulin A nephropathy (IgAN), APOL1-mediated kidney disease, and primary membranous nephropathy.
Major enrollment milestones for enoxaparin in AMKD and POVI in IgAN expected by year-end, with data for POVI in IgAN anticipated in the first half of 2026.
Regulatory filings for POVI and Zomylacell in type 1 diabetes are possible in 2026.
Ongoing dispute with Royalty Pharma over LifTrak royalties, expected to resolve by end of 2026.
Cystic fibrosis franchise and growth drivers
Survival benefits from CFTR modulators are driving market growth, with approvals expanding to younger patients and new geographies.
LifTrak targets rare mutations and patients who discontinued previous therapies, offering once-daily dosing and a favorable side effect profile.
VX-522, an inhaled mRNA therapy, is in development for patients not producing CFTR protein.
Majority of LifTrak prescriptions are switches from Trikafta, with additional liver monitoring required in the U.S.
Next-generation VX-828 aims to bring more patients to carrier-level sweat chloride, with patient trials expected before year-end.
Pain franchise and Jurnavix launch
Jurnavix achieved unrestricted access for 85 million U.S. lives by August, with ongoing negotiations to expand coverage.
Jurnavix is positioned as a non-opioid with a clean side effect profile, used primarily at discharge for acute pain, with average script duration of 14 days.
Two phase 3 studies in diabetic peripheral neuropathy (DPN) are underway, with enrollment expected to complete in 2026.
Strategy for chronic pain label is evolving based on FDA feedback, with potential for combination therapies in the future.
JOURNAVX: How to expand unrestricted access
Chronic pain: Broad PNP label strategy shift?
Pove: Key differentiators in IgAN market?
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Next Vertex Pharmaceuticals earnings date
Q3 20253 Nov, 2025
Next Vertex Pharmaceuticals earnings date
Q3 20253 Nov, 2025
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Frequently asked questions
Vertex Pharmaceuticals Incorporated, a biotechnology company, engages in developing and commercializing therapies for treating cystic fibrosis. Its products include KALYDECO (ivacaftor), ORKAMBI (lumacaftor and ivacaftor), SYMDEKO/SYMKEVI (tezacaftor/ivacaftor and ivacaftor), VX-445, and VX-659, as well as other product candidates at various stages of research, development, and commercialization. The company has collaboration agreements with CRISPR Therapeutics AG; Moderna, Inc.; CRISPR Therapeutics AG; Editas Medicine, Inc.; Frontline BioVentures; Merck & Co., Inc.; Cystic Fibrosis Foundation Therapeutics, Incorporated; Bristol-Myers Squibb Company; Altimmune, Inc.; and Tesaro, Inc. Vertex Pharmaceuticals Incorporated was founded in 1989 and is headquartered in Boston, Massachusetts.
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