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Vivoryon Therapeutics (VVY) investor relations material
Vivoryon Therapeutics Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary4 Sep, 2025
Executive summary
Focused on advancing varoglutamstat as a novel oral therapy for chronic and diabetic kidney disease, with strong clinical and preclinical evidence supporting efficacy and safety, and addressing significant unmet medical needs.
Achieved significant milestones in H1 2025, including positive Phase 2 data, new U.S. composition of matter patent for varoglutamstat (exclusivity through 2044, potential extension to 2049), and preparations for a Phase 2b DKD study.
Presented new preclinical and mechanistic data supporting efficacy in diabetic kidney disease and rare diseases like Fabry disease, with promising results in animal models and additive effects with SGLT-2 inhibitors.
Actively pursuing additional financing and partnerships to support late-stage clinical development and fund upcoming clinical trials.
Nomination of VY2149 as a next-generation QPCT/L inhibitor for future development.
Financial highlights
No revenue reported for H1 2025 or H1 2024.
R&D expenses for H1 2025 were €2.8M, down from €10.3M in H1 2024, mainly due to reduced clinical development and production costs.
G&A expenses decreased to €2.8M from €3.5M year-over-year, attributed to lower personnel and consulting costs.
Net loss narrowed to €5.5M in H1 2025 from €13.6M in H1 2024.
Cash and equivalents stood at €4.8M as of June 30, 2025, down from €9.4M at year-end 2024, with a runway into January 2026, excluding potential SEPA funds.
Outlook and guidance
Preparations for a dedicated Phase 2b study in diabetic kidney disease are underway, with protocol discussions ongoing and CRO selection in final stages; study start is contingent on securing additional funding or partnerships.
Top-line data from the Phase 2b study expected within 24 months of initiation.
Operating plan supports kidney disease strategy and IP strengthening.
Ongoing operating losses and need for further capital are anticipated for the foreseeable future.
Material uncertainty exists regarding the ability to continue as a going concern in 2026 without new funding.
What is the ideal partnership timing for Phase IIb?
What funding is needed for VY2149 preclinical?
What are key considerations for Phase IIb protocol?
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Next Vivoryon Therapeutics earnings date
Q3 20258 Dec, 2025
Next Vivoryon Therapeutics earnings date
Q3 20258 Dec, 2025
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Frequently asked questions
Vivoryon Therapeutics N.V., previously known as Probiodrug, is a Germany-based clinical-stage biopharmaceutical company. It specializes in the discovery and development of therapies for patients suffering from age-related diseases, with a primary focus on Alzheimer’s disease and cancer immune checkpoint inhibition. The company leverages its expertise in understanding post-translational modifications to develop small molecule medications that modulate the activity and stability of proteins altered in disease settings. The company is headquartered in Halle (Saale), Germany, and its shares are listed on the Euronext Amsterdam.
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