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VYNE Therapeutics (VYNE) investor relations material
VYNE Therapeutics Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary14 Aug, 2025
Executive summary
Cost reductions implemented, extending cash runway into the first half of 2027.
Pipeline focused on BET inhibitors for chronic inflammatory and immune-mediated diseases, with VYN202 and repibresib as lead candidates.
VYN202 Phase 1b trial in psoriasis showed promising preliminary efficacy; FDA clinical hold partially lifted for female subjects, with hold for males pending additional data.
Repibresib Phase 2b trial in vitiligo did not meet endpoints; program discontinued and seeking external partner.
Financial highlights
Net loss of $5.8M for Q2 2025, a 38.8% improvement year-over-year; $0.13 per share.
Cash, cash equivalents, and marketable securities totaled $39.6M as of June 30, 2025; no outstanding debt.
Total revenues of $0.1M for Q2 2025, down 65.2% year-over-year, primarily from royalty income.
Research and development expenses decreased 33.2% to $4.9M; general and administrative expenses down 17% to $2.7M in Q2 2025.
Operating loss for Q2 2025: $7.5M, a 27.5% improvement year-over-year.
Outlook and guidance
Cash runway expected to last into the first half of 2027 based on current operating assumptions.
Additional capital will be required for further development of VYN202 and other pipeline candidates.
Strategic review of pipeline and cost structure ongoing; seeking partners for repibresib.
Explain the impact of the vehicle effect on repibresib.
Assess the potential of VYN202 in pulmonology.
What is the status of finding a partner for repibresib?
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Next VYNE Therapeutics earnings date
Q3 202510 Nov, 2025
Next VYNE Therapeutics earnings date
Q3 202510 Nov, 2025
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Frequently asked questions
VYNE Therapeutics Inc. is a clinical-stage biopharmaceutical company dedicated to developing proprietary therapeutics for the treatment of immuno-inflammatory conditions. The company's product pipeline includes VYN201, a locally administered pan-BET inhibitor designed to address diseases involving multiple inflammatory cell signaling pathways with minimal systemic exposure. Additionally, VYNE is working on VYN202, a BD2-selective oral small molecule, and FMX114, a combination gel in clinical trials for atopic dermatitis. The company is headquartered in Bridgewater, New Jersey, and its shares are listed on the NASDAQ.
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