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Whitehawk Therapeutics (WHWK) investor relations material
Whitehawk Therapeutics H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary9 Sep, 2025
Company overview and pipeline
Recently relaunched as an ADC-focused company, licensing a portfolio from WuXi Biologics.
Pipeline includes three assets: two with IND filings planned for Q4 this year, and a third in mid-2026.
Expects to have three clinical assets by mid-2026, with data anticipated in early 2027.
Lead asset HWK-007 and competitive landscape
HWK-007 targets PCK7, a broadly expressed tumor marker in multiple cancers, with potential to treat hundreds of thousands of patients.
Preclinical data suggest superior activity compared to first-generation Pfizer compounds.
Differentiation is based on unique linker-payload chemistry, aiming for greater stability and reduced toxicity compared to competitors like Day One and Xencor.
Phase 1 trial will focus on non-small cell lung, ovarian, and endometrial cancers, with biomarker-driven patient selection.
Biomarker strategy includes an all-comers approach for gynecological cancers and a threshold-based approach for lung cancer, targeting 85% of the NSCLC market.
HWK-016 and MUC16 targeting
HWK-016 targets MUC16, a highly expressed marker in gynecological tumors, with a unique approach to avoid the circulating CA-125 sink.
The asset targets the membrane-bound portion of MUC16, aiming for improved tumor delivery.
No other ADCs currently target MUC16, providing a first-mover advantage.
Safety profile is designed to enable combinations with chemotherapies and IO-based therapies, including VEGF and PD-1 agents.
HWK-007 linker stability vs. competitors?
HWK-007 NSCLC biomarker strategy impact?
HWK-206 combination strategy for earlier lines?
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Next Whitehawk Therapeutics earnings date
Q3 20255 Nov, 2025
Next Whitehawk Therapeutics earnings date
Q3 20255 Nov, 2025
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