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Whitehawk Therapeutics (WHWK) investor relations material
Whitehawk Therapeutics Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Advanced two antibody-drug conjugates (HWK-007 and HWK-016) into active Phase 1 trials, targeting PTK7 and MUC16 in various cancers.
Appointed a new Chief Medical Officer with extensive oncology experience.
Presented data confirming PTK7 as a highly expressed, clinically relevant tumor marker.
Financial highlights
Cash, cash equivalents, and short-term investments totaled $145.7M at year-end 2025, up from $47.2M at year-end 2024.
Net loss for Q4 2025 was $23.3M, compared to $18.3M in Q4 2024.
Full-year 2025 net loss was $20.6M, significantly improved from $63.7M in 2024, aided by an $87.3M gain from the divestiture of a subsidiary.
Revenue for 2025 was $25.98M, up from $5.87M in 2024.
Outlook and guidance
Cash reserves expected to fund operations into 2028.
IND submission for HWK-206 planned for mid-2026, with Phase 1 trial recruitment to start in Q3 2026.
Initial Phase 1 results for HWK-007 and HWK-016 anticipated in 1H 2027.
Preclinical data across the portfolio to be presented in Spring 2026.
- Three differentiated ADCs progress toward key clinical milestones, with data expected by early 2027.WHWK
The Citizens Life Sciences Conference 202610 Mar 2026 - Three differentiated ADCs advance in parallel, targeting broad cancer indications with strong stability and safety.WHWK
TD Cowen 46th Annual Health Care Conference3 Mar 2026 - Advancing three differentiated ADCs with clinical data expected in 2027 and strong cash runway.WHWK
Oppenheimer 36th Annual Healthcare Life Sciences Conference25 Feb 2026 - Next-gen ADCs show superior preclinical results, with clinical data expected in early 2027.WHWK
Jefferies London Healthcare Conference 20253 Feb 2026 - FYARRO sales rose 15% sequentially; cash runway extends into Q4 2025 as trials advance.WHWK
Q2 20242 Feb 2026 - PRECISION1's interim data in Q3 could expand reach beyond PEComa, with pipeline trials progressing.WHWK
Jefferies 2024 Global Healthcare Conference1 Feb 2026 - $100M FYARRO sale, $100M PIPE, and ADC in-licensing drive late 2028 runway and clinical focus.WHWK
Investor Update10 Jan 2026 - Transformed into an ADC-focused company with robust funding and three INDs planned in 15 months.WHWK
Q4 202426 Dec 2025 - Oncology company pivots to ADC pipeline after $100M raise and asset sale; investors register shares.WHWK
Registration Filing16 Dec 2025
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