Xencor
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Xencor (XNCR) investor relations material

Xencor Q3 2026 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q3 2026 earnings summary4 Nov, 2026

Executive summary

  • Q3 revenue was $116.5M and net income was $39.4M, with diluted EPS of $0.50; results included $77.4M of one-time Alexion settlement revenue recognized as royalties.

  • Pipeline advanced: XmAb819 dose selection supported proposed Phase 3 planning, XmAb412 began enrolling in Phase 1, and a XmAb541/XmAb808 combination trial was initiated.

Financial highlights

  • Q3 revenue was $116.5M vs. $21.0M a year earlier, including $87.5M of royalties and $29.0M of milestones; 9M revenue was $172.3M vs. $97.3M.

  • Q3 operating income was $22.9M vs. a $47.5M loss; net income was $39.4M vs. a $6.0M loss, with diluted EPS of $0.50 vs. $(0.08).

  • 9M operating loss was $92.1M vs. $123.9M; net loss was $111.2M vs. $85.3M.

  • Q3 R&D expense rose to $84.3M from $54.4M, partly offset by lower stock compensation; G&A fell to $9.4M from $14.2M, primarily from a non-recurring legal expense recovery.

  • Q3 other income, net, was $16.4M vs. $41.5M, primarily reflecting lower unrealized equity-security gains; 9M R&D was $220.9M vs. $174.6M and G&A was $43.5M vs. $46.6M.

Outlook and guidance

  • Year-end 2026 cash, cash equivalents and marketable debt securities are expected at $480M–$500M; current resources are expected to support operations into 2029, subject to assumptions and potential milestone payments.

  • XmAb819 FDA engagement on a potential accelerated pathway is planned for 1H27; subject to feedback, a global randomized Phase 3 study may begin by year-end 2027.

  • XmAb942 blinded interim analysis is expected around year-end 2026, with its Phase 2b primary endpoint analysis targeted for 2H27.

  • Initial XmAb412 data and additional XmAb819 IV and subcutaneous cohort results are planned for 1H27.

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Frequently asked questions

Xencor Inc. is a clinical-stage biopharmaceutical company focused on developing engineered monoclonal antibodies and cytokine therapies for the treatment of cancer and autoimmune diseases. The company utilizes its proprietary XmAb technology to create antibody-based therapies that enhance immune responses or modulate immune activity. Xencor's pipeline includes candidates designed to target specific proteins involved in disease processes, aiming to provide more effective and durable treatments. The company is involved in both internal research and collaborations with other biopharma companies to advance its therapies through clinical trials. The company is headquartered in Monrovia, California, and its shares are listed on the NASDAQ.