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Zymeworks (ZYME) investor relations material
Zymeworks Q3 2026 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Q3 2026 revenue was $256.5M, including a $250M Jazz milestone for Ziihera’s U.S. first-line GEA approval; net income was $173.7M and diluted EPS was $2.28.
FY 2026 revenue guidance rose to $337M–$351M and Adjusted EBITDA guidance to $176M–$190M.
Theravance added YUPELRI economics and VIBATIV royalties; the Roche ZW209 collaboration offers milestone and royalty potential.
Strategy emphasizes royalty and asset aggregation, focused R&D, partnerships and selective acquisitions; FY 2026 profitability is expected, but not consistent quarterly profitability near to medium term.
Financial highlights
Q3 revenue was $256.5M vs. $27.6M; operating income was $177.6M vs. an operating loss of $22.1M; net income was $173.7M vs. a net loss of $19.6M.
9M revenue was $263.5M vs. $103.5M; operating income was $88.3M vs. an operating loss of $48.4M; net income was $84.5M vs. a net loss of $39.9M.
Q3 R&D was $36.1M vs. $35.6M; SG&A was $42.7M vs. $14.1M, reflecting acquisition costs, severance, professional fees and higher stock compensation.
9M R&D was $98.0M, down $7.8M YoY; SG&A was $77.1M, up $31.0M, mainly from acquisition-related severance, fees and stock compensation.
Adjusted EBITDA was $215.3M in Q3 vs. negative $13.5M; 9M Adjusted EBITDA was $153.0M vs. negative $21.3M.
Outlook and guidance
FY 2026 revenue guidance increased to $337M–$351M from $278M–$292M; Adjusted EBITDA guidance increased to $176M–$190M from $114M–$128M, excluding future transactions.
Guidance is subject to expiration or termination of the Roche collaboration HSR waiting period, expected in Q4 2026.
Existing cash plus the $250M Jazz milestone collected in October is expected to fund operating and capital needs for at least 12 months from filing; assessment excludes contingent milestones and strategic transactions.
Annual R&D expense, excluding stock-based compensation, is expected to trend lower over several years; collaborations are intended to share later-stage development costs.
A $100M TRELEGY ELLIPTA milestone is expected in Q1 2027, conditional on 2026 global sales thresholds; up to $190M in additional Ziihera GEA regulatory milestones remains possible.
- Royalty cash flows fund a partnered R&D engine and selective value compounding.ZYME
Corporate presentation - Shareholders face six proposals, including a transition to annual director elections by 2029.ZYME
Proxy filing - Six votes include board declassification, a new stock plan and a 1-year say-on-pay cadence.ZYME
Proxy filing - Roche licenses ZW209 as ZW191 and ZIIHERA data bolster the portfolio.ZYME
Investor update - A six-proposal agenda pairs a new ESPP with a path to annual director elections by 2029.ZYME
Proxy filing - Theravance adds YUPELRI cash flows and R&D upside, funded by a non-recourse note.ZYME
M&A announcement - FDA approval, robust pipeline, and strategic partnerships drive growth and shareholder value.ZYME
Morgan Stanley 24th Annual Global Healthcare Conference - Scalable growth driven by partnerships, robust pipeline, and strong financial outlook.ZYME
Corporate presentation - FDA approval for zanidatamab and strategic acquisitions drive growth and innovation.ZYME
Wells Fargo 21st Annual Healthcare Conference
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