Zymeworks
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Zymeworks (ZYME) investor relations material

Zymeworks Q3 2026 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q3 2026 earnings summary9 Nov, 2026

Executive summary

  • Q3 2026 revenue was $256.5M, including a $250M Jazz milestone for Ziihera’s U.S. first-line GEA approval; net income was $173.7M and diluted EPS was $2.28.

  • FY 2026 revenue guidance rose to $337M–$351M and Adjusted EBITDA guidance to $176M–$190M.

  • Theravance added YUPELRI economics and VIBATIV royalties; the Roche ZW209 collaboration offers milestone and royalty potential.

  • Strategy emphasizes royalty and asset aggregation, focused R&D, partnerships and selective acquisitions; FY 2026 profitability is expected, but not consistent quarterly profitability near to medium term.

Financial highlights

  • Q3 revenue was $256.5M vs. $27.6M; operating income was $177.6M vs. an operating loss of $22.1M; net income was $173.7M vs. a net loss of $19.6M.

  • 9M revenue was $263.5M vs. $103.5M; operating income was $88.3M vs. an operating loss of $48.4M; net income was $84.5M vs. a net loss of $39.9M.

  • Q3 R&D was $36.1M vs. $35.6M; SG&A was $42.7M vs. $14.1M, reflecting acquisition costs, severance, professional fees and higher stock compensation.

  • 9M R&D was $98.0M, down $7.8M YoY; SG&A was $77.1M, up $31.0M, mainly from acquisition-related severance, fees and stock compensation.

  • Adjusted EBITDA was $215.3M in Q3 vs. negative $13.5M; 9M Adjusted EBITDA was $153.0M vs. negative $21.3M.

Outlook and guidance

  • FY 2026 revenue guidance increased to $337M–$351M from $278M–$292M; Adjusted EBITDA guidance increased to $176M–$190M from $114M–$128M, excluding future transactions.

  • Guidance is subject to expiration or termination of the Roche collaboration HSR waiting period, expected in Q4 2026.

  • Existing cash plus the $250M Jazz milestone collected in October is expected to fund operating and capital needs for at least 12 months from filing; assessment excludes contingent milestones and strategic transactions.

  • Annual R&D expense, excluding stock-based compensation, is expected to trend lower over several years; collaborations are intended to share later-stage development costs.

  • A $100M TRELEGY ELLIPTA milestone is expected in Q1 2027, conditional on 2026 global sales thresholds; up to $190M in additional Ziihera GEA regulatory milestones remains possible.

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Stifel 2026 Healthcare Conference 202611 Nov, 2026
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Frequently asked questions

Zymeworks Inc. is a clinical-stage biopharmaceutical company dedicated to the discovery, development and commercialization of next-generation bispecific, multifunctional biotherapeutics, initially focused on the treatment of cancer. The company's proprietary Azymetric platform combines its modular and flexible Fc engineering with non-Fc-containing domains designed to enable modulation of therapeutic index in order to address multiple biological targets simultaneously from a single protein. The partnering team brings together a comprehensive set of skills and expertise spanning early drug discovery through product commercialization.