Spyre Therapeutics (SYRE) Proxy filing summary

Voting matters and shareholder proposals

• Election of three Class I Directors for terms expiring in 2029, with board recommendation to vote for all nominees.

• Advisory vote to approve compensation of named executive officers, recommended for approval.

• Ratification of KPMG LLP as independent registered public accounting firm for the year ending December 31, 2026, recommended for approval.

• Approval of amended and restated 2016 Employee Stock Purchase Plan, recommended for approval.

• Provision for other business to be addressed as may properly come before the meeting.

Board of directors and corporate governance

• Nominees for Class I Director positions include Mark McKenna, Cameron Turtle, D.Phil., and Laurie Stelzer.

• Directors, if elected, will serve until 2029.

Executive compensation and say-on-pay

• Advisory vote scheduled to approve compensation of named executive officers.