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Edge12 Dec 2025
Running on Clouds: The Story of On
The story of how a Swiss runner's pursuit of a new running sensation became On, aiming to be the most premium global sportswear brand worldwide.
Alector (ALEC) investor relations material
Alector BofA Securities CNS Therapeutics Virtual Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.BofA Securities CNS Therapeutics Virtual Conference 2025 summary8 Dec, 2025
Company and pipeline overview
Focus on neurodegenerative diseases with five drugs advanced to the clinic, including a Progranulin-elevating drug for Alzheimer's in partnership with GSK, with phase II interim analysis expected in the first half of next year.
Multiple preclinical programs leverage proprietary Blood-Brain Barrier (BBB) technology to enhance brain delivery of large molecules.
Pipeline includes anti-amyloid-β antibody, GCase enzyme replacement therapy for Parkinson's and Lewy body dementia, and a portfolio of BBB-enabled siRNA programs targeting Tau, α-synuclein, and NLRP3.
Blood-Brain Barrier technology and ABC platform
BBB technology enables 10-50x higher brain concentrations of drugs, allowing lower peripheral doses and improved safety.
Uses transferrin receptor as a transport mechanism, with unique epitope and affinity optimizations to maximize brain delivery and minimize anemia risk.
Platform is highly adaptable, allowing for different drug modalities and configurations tailored to each therapeutic target.
Drug configuration, transferrin affinity, and epitope selection are optimized for each modality to balance efficacy, safety, and pharmacokinetics.
Anti-amyloid-β antibody (AL137) program
AL137 and its backup show 4-12x higher brain penetration than competitors, aiming for subcutaneous delivery and lower dose to reduce safety risks.
Phase I studies will use amyloid PET imaging and ARIA monitoring in small cohorts to assess amyloid clearance and safety early.
Targeting a clinic entry in 2026, with rapid assessment of efficacy and safety endpoints.
ABC platform: anemia mitigation strategy
AL101: Universal neurodegeneration risk gene impact
AL50: Strategy for sporadic Parkinson's patients
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Next Alector earnings date
Q4 202525 Feb, 2026
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Frequently asked questions
Alector, Inc., a clinical stage biopharmaceutical company, develops therapies for the treatment of neurodegeneration diseases. The company is developing AL001, an antibody that targets delta-like ligand 4-Notch to address abnormal signaling triggered by microglia in Alzheimer's disease prevention and slowing in patients with mild cognitive impairment and early-stage Alzheimer's disease; AL101, an anti-TREM2 antibody targeting microglia function that is in Phase IIa clinical trial for the treatment of frontotemporal dementia; AL003, an anti-LINGO monoclonal antibody targeting oligodendrocyte precursor cells for myelination; and AL002 and AL004 for preventing or slowing disease progression in Parkinson's disease. The company was founded in 2013 and is headquartered in South San Francisco, California.
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