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Investor Relations14 Oct 2025
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Alector (ALEC) investor relations material
Alector Study Update summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Study Update summary22 Sep, 2025
Pipeline overview and strategy
Focus on developing disease-modifying therapies for neurodegenerative diseases using a three-pronged approach: removing misfolded proteins, replacing deficient proteins, and restoring dysfunctional cells.
Proprietary Electro Brain Carrier (ABC) technology enhances delivery of therapeutics across the blood-brain barrier, enabling delivery of antibodies, enzymes, and siRNA with tailored configurations.
Late-stage pipeline includes progranulin-elevating antibodies for FTD-GRN and Alzheimer's, with additional ABC-enabled programs in preclinical development for Alzheimer's, Parkinson's, Lewy body dementia, Gaucher disease, and other neurodegenerative diseases.
Strong financial position with over $300 million in cash, operational runway into the second half of 2027, and a partnership with GSK including $700M upfront, $1.5B in milestones, 50/50 U.S. profit share, and tiered royalties ex-U.S.
Progranulin-elevating franchise (FTD-GRN and Alzheimer's disease)
Latazimumab/latozinemab (for FTD-GRN) has received breakthrough, fast track, and orphan drug designations; pivotal Phase 3 (INFRONT-3) top-line data expected mid-Q4 2024–2025.
Nivisibart/nivisnebart (for Alzheimer's) is fully enrolled in a Phase 2 trial (PROGRESS-AD), with interim analysis expected in 1H 2026.
Both antibodies increase progranulin by blocking SORT1, restoring levels and showing two- to threefold increases in clinical trials, with normalization of key biomarkers and 48% slowing of clinical progression in FTD-GRN.
INFRONT-3 is a 96-week, global, placebo-controlled trial with co-primary endpoints of clinical progression and plasma progranulin.
Clinical and regulatory updates
FDA requested plasma progranulin as a co-primary endpoint for INFRONT-3; both clinical and biomarker endpoints must meet p<0.05 for success.
Sensitivity analysis will include asymptomatic carriers; further label expansion discussions pending data.
If Phase 3 is positive, company is prepared for rapid BLA filing and commercial manufacturing.
FTD-GRN patient identification strategy?
ABC-enabled siRNA: delivery and efficacy?
AL050's advantage over current GKs ERT?
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Next Alector earnings date
Q3 20255 Nov, 2025
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Frequently asked questions
Alector, Inc., a clinical stage biopharmaceutical company, develops therapies for the treatment of neurodegeneration diseases. The company is developing AL001, an antibody that targets delta-like ligand 4-Notch to address abnormal signaling triggered by microglia in Alzheimer's disease prevention and slowing in patients with mild cognitive impairment and early-stage Alzheimer's disease; AL101, an anti-TREM2 antibody targeting microglia function that is in Phase IIa clinical trial for the treatment of frontotemporal dementia; AL003, an anti-LINGO monoclonal antibody targeting oligodendrocyte precursor cells for myelination; and AL002 and AL004 for preventing or slowing disease progression in Parkinson's disease. The company was founded in 2013 and is headquartered in South San Francisco, California.
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