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Alector (ALEC) investor relations material
Alector Study Update summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Pipeline overview and strategy
Focus on developing disease-modifying therapies for neurodegenerative diseases using a three-pronged approach: removing misfolded proteins, replacing deficient proteins, and restoring dysfunctional cells.
Proprietary Electro Brain Carrier (ABC) technology enhances delivery of therapeutics across the blood-brain barrier, enabling delivery of antibodies, enzymes, and siRNA with tailored configurations.
Late-stage pipeline includes progranulin-elevating antibodies for FTD-GRN and Alzheimer's, with additional ABC-enabled programs in preclinical development for Alzheimer's, Parkinson's, Lewy body dementia, Gaucher disease, and other neurodegenerative diseases.
Strong financial position with over $300 million in cash, operational runway into the second half of 2027, and a partnership with GSK including $700M upfront, $1.5B in milestones, 50/50 U.S. profit share, and tiered royalties ex-U.S.
Progranulin-elevating franchise (FTD-GRN and Alzheimer's disease)
Latazimumab/latozinemab (for FTD-GRN) has received breakthrough, fast track, and orphan drug designations; pivotal Phase 3 (INFRONT-3) top-line data expected mid-Q4 2024–2025.
Nivisibart/nivisnebart (for Alzheimer's) is fully enrolled in a Phase 2 trial (PROGRESS-AD), with interim analysis expected in 1H 2026.
Both antibodies increase progranulin by blocking SORT1, restoring levels and showing two- to threefold increases in clinical trials, with normalization of key biomarkers and 48% slowing of clinical progression in FTD-GRN.
INFRONT-3 is a 96-week, global, placebo-controlled trial with co-primary endpoints of clinical progression and plasma progranulin.
Clinical and regulatory updates
FDA requested plasma progranulin as a co-primary endpoint for INFRONT-3; both clinical and biomarker endpoints must meet p<0.05 for success.
Sensitivity analysis will include asymptomatic carriers; further label expansion discussions pending data.
If Phase 3 is positive, company is prepared for rapid BLA filing and commercial manufacturing.
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