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BioAge Labs (BIOA) investor relations material
BioAge Labs Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Key clinical data and program updates
Announced first clinical results for a brain-penetrant NLRP3 inhibitor, showing target coverage in brain and periphery at 60 mg and complete IL-1 beta shutoff at 120 mg, with good safety and tolerability.
Initial phase 1 included SAD and two MAD cohorts in healthy volunteers, with 60 mg and 120 mg doses; 120 mg achieved full IL-1 beta suppression.
Three individuals with elevated CRP in MAD cohorts saw an average 79.5% CRP reduction.
Two new MAD cohorts in obese patients with high CRP will read out in the first half of next year, followed by a 12-week study starting mid-next year.
No dose-limiting toxicity observed; safety margins over 40-fold at 60 mg, with only mild to moderate AEs.
Strategic focus and indication prioritization
Next proof-of-concept (POC) study will focus on CRP reduction in obese individuals with cardiovascular risk, not obesity as a primary endpoint.
Indication selection will target areas where the company can advance alone through phase 3, leveraging unique brain and retina penetration.
Additional indications, including neurodegenerative and ocular diseases, are under consideration, with plans to announce next year.
Differentiation from competitors includes a novel NLRP3 binding site, best-in-class potency, and brain penetration.
Portfolio includes a follow-on brain-penetrant compound and potent peripherally restricted NLRP3 inhibitors.
Financial and operational outlook
Cash balance of ~$300 million and runway of about three years, covering planned studies and APJ programs through phase 1.
Strategy includes advancing some indications independently and partnering for larger indications like ASCVD and Alzheimer's.
Discovery platform leveraged DNA-encoded library screening and structural biology collaborations, resulting in novel compounds.
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