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BioInvent International (BINV) investor relations material
BioInvent International Corporate presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Pipeline and clinical programs
Two lead antibodies, BI-1808 (anti-TNFR2) and BI-1206 (anti-FcyRIIB), have demonstrated clinical proof of concept in ovarian cancer, NSCLC, CTCL, uveal melanoma, and NHL.
BI-1808 shows single-agent activity and durable responses in ovarian cancer and CTCL, with potential to become a new standard of care.
BI-1206 targets resistance mechanisms in follicular lymphoma and solid tumors, showing significant efficacy in combination regimens.
Multiple Phase 2a readouts are expected in mid-2026 for both programs, with pivotal studies planned for 2027.
Complete and partial responses have been observed across all clinical programs.
BI-1808 (anti-TNFR2) highlights
Demonstrates a differentiated mechanism by depleting regulatory T cells, activating myeloid cells, and expanding CD8+ T cells.
In ovarian cancer, BI-1808 plus pembrolizumab achieved a 24% ORR and 57% DCR, with durable responses and manageable safety profile.
In CTCL, monotherapy showed a 46% ORR and 92% DCR, with early immune activation and favorable safety.
Potential blockbuster opportunity in ovarian cancer and CTCL, addressing large, underserved markets.
Planned data releases in 2026 include Phase 2a updates for both monotherapy and combination regimens.
BI-1206 (anti-FcyRIIB) highlights
Blocks a key resistance pathway to antibody therapies, resensitizing tumors to CD20 therapy in follicular lymphoma.
In combination with rituximab, BI-1206 achieved a 59% ORR and 41% CRR in follicular lymphoma, with long-lasting responses.
Triplet therapy (BI-1206 + rituximab + acalabrutinib) showed an 80% ORR and 100% DCR in NHL, with good tolerability.
In solid tumors, BI-1206 plus pembrolizumab demonstrated durable responses in anti-PD-1 refractory melanoma and uveal melanoma.
Ongoing Phase 2a studies in NSCLC and uveal melanoma, with first data expected in H2 2026.
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