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Bristol-Myers Squibb Company (BMY) investor relations material
Bristol-Myers Squibb Company Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Q3 2025 revenues rose 3% year-over-year to $12.2 billion, driven by 17–18% growth in the Growth Portfolio and robust demand across key brands including Opdivo, Reblozyl, Camzyos, and Breyanzi.
Achieved multiple clinical and regulatory milestones, including breakthrough therapy and fast track designations, and regulatory approvals for Breyanzi, Camzyos, Opdivo + Yervoy, and Opdivo Qvantig.
Strategic business development included the acquisition of Orbital Therapeutics, collaborations with BioNTech and Philochem, and key licensing agreements, expanding cell therapy and radiopharmaceutical platforms.
Expanded productivity initiatives targeting $2.0 billion in annual cost savings by 2027, with continued focus on cost discipline, digital transformation, and operational efficiency.
Business development and pipeline progress support long-term sustainable growth.
Financial highlights
Q3 2025 sales reached $12.2 billion, up 3% year-over-year, with Growth Portfolio revenues up 18% to $6.9 billion and Legacy Portfolio revenues down 12% to $5.4 billion.
GAAP EPS was $1.08, non-GAAP EPS was $1.63, both impacted by acquired IPR&D charges and licensing income.
Gross margin was 71.9% (GAAP) and 72.9% (non-GAAP); operating expenses were $4.2–$4.3 billion, down year-over-year.
Cash flow from operations was $3.9–$6.3 billion in Q3; cash and equivalents at quarter-end were $15.7–$17 billion.
Net debt position improved by $6.4–$6.7 billion since year-end, with $6.7 billion of $10 billion debt paydown completed.
Outlook and guidance
Full-year 2025 revenue guidance raised to $47.5–$48.0 billion, reflecting strong Growth Portfolio performance.
Non-GAAP EPS guidance narrowed to $6.40–$6.60, including $(0.80) per share net impact from acquired IPR&D charges.
Legacy Portfolio sales expected to decline 15–17% for the year; Revlimid sales projected at $3 billion.
Gross margin guidance at 72%; operating expense guidance at $16.5 billion, with over $1 billion in net savings vs. 2024.
Ongoing cost savings from productivity initiatives and favorable tax legislation expected to support sustainable growth.
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