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Bristol-Myers Squibb Company (BMY) investor relations material
Bristol-Myers Squibb Company Bernstein Insights: Healthcare Leaders and Disruptors - 2nd Annual Healthcare Forum summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Bernstein Insights: Healthcare Leaders and Disruptors - 2nd Annual Healthcare Forum summary23 Sep, 2025
Market dynamics and access challenges
CAR T therapies have transformative potential but face adoption barriers due to delivery limitations in community practices and referral patterns, especially in the U.S.
France leads in CAR T adoption due to integrated healthcare systems, while the U.S. and other countries lag due to fragmented care and access issues.
Recent regulatory changes, such as reduced REMS requirements, are expected to improve patient access and reduce treatment burden.
Efforts are underway to expand CAR T delivery into community oncology centers, with early success in select locations.
Only 20% of eligible U.S. patients currently receive CAR T, highlighting significant growth potential.
Innovation and pipeline development
The pipeline includes best-in-class and first-in-class CAR Ts, such as GPRC5D (Orva-cel) and dual-targeting CARs for multiple myeloma, and CD19 Breyanzi for B-cell malignancies.
Orva-cel shows promising efficacy and safety in both BCMA-naive and BCMA-exposed patients, with pivotal data expected next year.
Dual-targeting CARs aim to address high unmet needs in newly diagnosed multiple myeloma, balancing efficacy and safety.
Investments are being made in off-the-shelf (allo) and in vivo CAR T platforms, with early clinical progress in autoimmune indications.
The company is pursuing basket trial designs to accelerate development across multiple autoimmune diseases.
Performance drivers and differentiation
Manufacturing improvements and a broad indication set have driven Breyanzi to top market share in several countries.
Breyanzi's safety profile enables outpatient administration, freeing up inpatient capacity and supporting further growth.
Seasonality affects CAR T utilization, but ongoing label updates and outpatient expansion are expected to drive long-term growth.
The company is proactively building physician networks and ecosystems to support CAR T adoption in both hematology and immunology.
What unlocks CAR-T use in community settings?
Future of CAR-T beyond autologous?
What enables CAR-T success in immunology?
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Next Bristol-Myers Squibb Company earnings date
Q3 202530 Oct, 2025
Next Bristol-Myers Squibb Company earnings date
Q3 202530 Oct, 2025
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Frequently asked questions
Bristol-Myers Squibb Company is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. It offers pharmaceutical products to treat psychiatric; cardiovascular diseases consisting of cholesterol disorders, hypertension, and arrhythmias; diabetes; human immunodeficiency virus infection; hepatitis B and hepatitis C viruses; infectious diseases comprising bacterial infections, mycobacterium avium complex disease, malaria, fungal infections tuberculosis, and influenza A/B virus; cancer comprising lymphoma, leukemia, and other cancers; diseases relating to inflammatory response of the body; rheumatoid arthritis and osteoarthritis related inflammation; psoriasis; Crohn's disease. The company also provides over-the-counter products for the treatment of acne and cold sores.
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