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Bristol-Myers Squibb Company (BMY) investor relations material

Bristol-Myers Squibb Company Q3 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q3 2025 earnings summary30 Oct, 2025

Executive summary

  • Q3 2025 revenues rose 3% year-over-year to $12.2 billion, driven by 17–18% growth in the Growth Portfolio and robust demand across key brands including Opdivo, Reblozyl, Camzyos, and Breyanzi.

  • Achieved multiple clinical and regulatory milestones, including breakthrough therapy and fast track designations, and regulatory approvals for Breyanzi, Camzyos, Opdivo + Yervoy, and Opdivo Qvantig.

  • Strategic business development included the acquisition of Orbital Therapeutics, collaborations with BioNTech and Philochem, and key licensing agreements, expanding cell therapy and radiopharmaceutical platforms.

  • Expanded productivity initiatives targeting $2.0 billion in annual cost savings by 2027, with continued focus on cost discipline, digital transformation, and operational efficiency.

  • Business development and pipeline progress support long-term sustainable growth.

Financial highlights

  • Q3 2025 sales reached $12.2 billion, up 3% year-over-year, with Growth Portfolio revenues up 18% to $6.9 billion and Legacy Portfolio revenues down 12% to $5.4 billion.

  • GAAP EPS was $1.08, non-GAAP EPS was $1.63, both impacted by acquired IPR&D charges and licensing income.

  • Gross margin was 71.9% (GAAP) and 72.9% (non-GAAP); operating expenses were $4.2–$4.3 billion, down year-over-year.

  • Cash flow from operations was $3.9–$6.3 billion in Q3; cash and equivalents at quarter-end were $15.7–$17 billion.

  • Net debt position improved by $6.4–$6.7 billion since year-end, with $6.7 billion of $10 billion debt paydown completed.

Outlook and guidance

  • Full-year 2025 revenue guidance raised to $47.5–$48.0 billion, reflecting strong Growth Portfolio performance.

  • Non-GAAP EPS guidance narrowed to $6.40–$6.60, including $(0.80) per share net impact from acquired IPR&D charges.

  • Legacy Portfolio sales expected to decline 15–17% for the year; Revlimid sales projected at $3 billion.

  • Gross margin guidance at 72%; operating expense guidance at $16.5 billion, with over $1 billion in net savings vs. 2024.

  • Ongoing cost savings from productivity initiatives and favorable tax legislation expected to support sustainable growth.

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Frequently asked questions

Bristol-Myers Squibb Company is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. It offers pharmaceutical products to treat psychiatric; cardiovascular diseases consisting of cholesterol disorders, hypertension, and arrhythmias; diabetes; human immunodeficiency virus infection; hepatitis B and hepatitis C viruses; infectious diseases comprising bacterial infections, mycobacterium avium complex disease, malaria, fungal infections tuberculosis, and influenza A/B virus; cancer comprising lymphoma, leukemia, and other cancers; diseases relating to inflammatory response of the body; rheumatoid arthritis and osteoarthritis related inflammation; psoriasis; Crohn's disease. The company also provides over-the-counter products for the treatment of acne and cold sores.

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