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Guardant Health (GH) investor relations material
Guardant Health Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler 37th Annual Healthcare Conference summary2 Dec, 2025
Revenue targets and product mix
Targeting $2.2 billion in revenue by 2028, with oncology products contributing over 60% ($1.4 billion).
Oncology revenue expected to more than double in three years, driven by Guardant360, Tissue, and Reveal.
Biopharma projected to grow from $200 million to $300 million by 2028.
Screening segment (Shield) forecasted to reach $500 million and 25% of revenue by 2028, with 700,000 tests.
Growth drivers and product innovation
Guardant360 maintains 30% annual growth, now driven by increased orders per oncologist and smart app launches.
Reveal is the fastest-growing oncology product, with new indications planned.
Monitoring opportunities, such as SERENA-6 approval, could increase test frequency per patient.
Strong flywheel effect expected from therapy selection and monitoring cycles using Guardant360 and Reveal.
Reimbursement, pricing, and margins
Reveal's ASP targeted at $1,000 by 2028, up from $600–$700, driven by Medicare reimbursement for new indications.
Shield's ASP benefits from Medicare ADLT pricing at $1,495, with cost per test reduced below $500 and aiming for $200.
Long-term operating margins for Shield expected to exceed 20%, with gross margins across the portfolio targeted at 65–70% by 2028.
Reveal ADLT status and ASP drivers
Shield: path to $200 COGS and 20%+ operating margin
Guardant360 growth drivers and monitoring flywheel
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Next Guardant Health earnings date
Q4 202520 Feb, 2026
Next Guardant Health earnings date
Q4 202520 Feb, 2026
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Frequently asked questions
Guardant Health, Inc. is a cancer-specific diagnostic company that provides blood tests, data sets, and analytics. The company's blood test detects cancer mutations in blood so that clinicians can prescribe medicines to match specific types of cancer. The company also provides its patient data sets and analytic tools to change the way hospitals model cancer outcomes. The company is based in Redwood City, California.
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