Guardant Health
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Guardant Health (GH) investor relations material

Guardant Health TD Cowen 46th Annual Health Care Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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TD Cowen 46th Annual Health Care Conference summary4 Mar, 2026

Business performance and growth outlook

  • 2025 saw exceptional growth, with accelerating momentum expected to continue into 2026, driven by multiple products gaining market traction.

  • Guardant360 experienced 25% volume growth in 2025, with 30% in the second half; 2026 guidance is for 20% growth, supported by deeper market penetration and new applications.

  • Reveal volumes grew over 80% in late 2025, with strong expectations for 2026, especially as new applications and reimbursement catalysts emerge.

  • SHIELD is projected to more than double its 2025 volume in 2026, supported by expanded sales force and the Quest partnership.

  • All business segments are described as “firing on all cylinders,” with continued innovation and market adoption anticipated.

Product innovation and portfolio strategy

  • Transition to a smart liquid biopsy platform with broad epigenetic profiling is driving innovation and adoption.

  • Multiple new applications are planned for launch, with over a dozen in the pipeline, enhancing clinical utility and physician engagement.

  • Reveal Ultra will launch in 2026, expanding into tumor-informed MRD testing.

  • The portfolio is evolving from individual tests to an integrated platform, improving patient management and customer retention.

  • The app ecosystem allows tailored solutions for different cancer types, supporting diverse clinical needs.

Regulatory and reimbursement developments

  • FDA approval for the flagship liquid biopsy test is expected in the second half of 2026, consolidating the portfolio and simplifying ordering.

  • FDA approval will also enable a new ADLT rate in 2027, potentially boosting both liquid and tissue test volumes and financial performance.

  • Medicare coverage for Reveal breast and reimbursement for therapy response monitoring are anticipated as major volume catalysts.

  • ACS guideline endorsement for SHIELD is expected soon, which could drive significant volume and commercial reimbursement, especially in states mandating ACS compliance.

Quantify G360 FDA approval's TissueNext volume boost
Shield Quest partnership: volume impact specifics
Reveal Ultra: Differentiated performance and integration
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Leerink Global Healthcare Conference 202610 Mar, 2026
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Frequently asked questions

Guardant Health, Inc. is a cancer-specific diagnostic company that provides blood tests, data sets, and analytics. The company's blood test detects cancer mutations in blood so that clinicians can prescribe medicines to match specific types of cancer. The company also provides its patient data sets and analytic tools to change the way hospitals model cancer outcomes. The company is based in Redwood City, California.

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