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Guardant Health
Guardant Health (GH) investor relations material
Guardant Health Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary19 Feb, 2026
Executive summary
Achieved a breakout year in 2025 with Q4 revenue up 39% and full-year revenue up 33%, driven by innovation, new product launches, and strong adoption across oncology, screening, and biopharma segments.
Oncology segment saw 30% revenue growth and 38% volume growth in Q4, supported by product upgrades and expanded reimbursement.
Screening segment experienced significant momentum, with Shield test volumes rising from 6,000 in Q4 2024 to 38,000 in Q4 2025 and revenue increasing from $4M to $35M.
Biopharma & Data revenue grew 18% to $210.1M in 2025, supported by new CDx approvals and strategic partnerships.
Expanded commercial and R&D activities, including new applications, strategic collaborations, and acquisitions.
Financial highlights
Q4 2025 revenue reached $281.3M, up 39% year-over-year; full-year revenue was $982M, up 33% from $739M in 2024.
Non-GAAP gross margin improved to 66% in Q4 and full year, up from 63% and 62% in 2024, respectively.
Adjusted EBITDA loss improved to $64.9M in Q4 and $220.9M for the year.
Ended 2025 with $1.3B in cash, cash equivalents, and marketable debt securities.
Free cash flow burn improved to $(54.2)M in Q4 and $(233.1)M for the year.
Outlook and guidance
2026 revenue expected at $1.25B–$1.28B (27%–30% growth), with oncology revenue up 25%–27% and screening revenue $162M–$174M from 210,000–225,000 Shield tests.
Non-GAAP gross margin forecasted at 64%–65%; operating expenses to grow 14%–16%.
Free cash flow burn expected at $185M–$195M, with core business (excluding screening) free cash flow positive.
Targeting free cash flow breakeven in Q4 2027.
Multiple new product launches and reimbursement advances anticipated in oncology and screening.
Detail Shield's 2026 volume growth drivers
Reconcile 2026 FCF improvement with lower gross margin
When will Merck collaboration revenue impact?
Shield commercial investment impact on FCF?
Reveal Ultra differentiation and market impact?
MetaSight acquisition: strategic value and tech fit?
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Next Guardant Health earnings date
TD Cowen 46th Annual Health Care Conference4 Mar, 2026
Guardant Health
Next Guardant Health earnings date
TD Cowen 46th Annual Health Care Conference4 Mar, 2026
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Frequently asked questions
Guardant Health, Inc. is a cancer-specific diagnostic company that provides blood tests, data sets, and analytics. The company's blood test detects cancer mutations in blood so that clinicians can prescribe medicines to match specific types of cancer. The company also provides its patient data sets and analytic tools to change the way hospitals model cancer outcomes. The company is based in Redwood City, California.
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