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Immunocore Holdings (IMCR) investor relations material

Immunocore Holdings Morgan Stanley 23rd Annual Global Healthcare Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Morgan Stanley 23rd Annual Global Healthcare Conference summary10 Sep, 2025

Competitive landscape and innovation

  • China is seen as both a competitor and opportunity in biotech, especially in immunology and cell therapy.

  • Maintaining a leading edge in TCR platform innovation is a priority.

  • AI is leveraged for operational efficiency and R&D, including target identification and clinical data analysis.

  • AI is expected to have a profound long-term impact on the industry.

  • Regulatory clarity, especially from the FDA, is crucial for investment and asset development decisions.

Product performance and market expansion

  • KIMMTRAK, approved for metastatic uveal melanoma, generated $192M in H1 with 32% YoY growth, but growth is expected to moderate as market matures.

  • U.S. penetration is nearing 70%, with potential to reach 80%+ as seen in Europe.

  • Global expansion includes launches in 28 countries and a new distribution agreement for MENA and Turkey.

  • Real-world duration of therapy now exceeds clinical trial results, reaching 13–14 months.

  • Safety profile is manageable, supporting broader community adoption.

Pipeline and clinical development

  • Two phase 3 trials for KIMMTRAK: advanced cutaneous melanoma (TEBE-AM) and adjuvant uveal melanoma (ADAM).

  • TEBE-AM enrollment to complete in H1 next year, with data expected in H2, subject to event-driven endpoints.

  • ADAM trial is enrolling in Europe and the U.S., with data expected after several years.

  • PRAME-targeted phase 3 (PRISM-MEL) in frontline cutaneous melanoma is ongoing, with dose selection built into the design.

  • Additional PRAME studies in ovarian and lung cancer are underway, with data expected within 12 months.

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Frequently asked questions

Immunocore Holdings plc is a commercial-stage biotechnology company focused on the development of innovative immunotherapies for cancer, infectious diseases, and autoimmune diseases. Utilizing its proprietary T cell receptor (TCR) technology, the company aims to create transformative medicines to address unmet medical needs. Among its notable products is KIMMTRAK, designed for the treatment of patients with unresectable or metastatic uveal melanoma. Immunocore is headquartered in Abingdon, the United Kingdom, and is listed on the NASDAQ stock exchange under the ticker symbol IMCR.

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