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Kiniksa Pharmaceuticals International (KNSA) investor relations material
Kiniksa Pharmaceuticals International Wells Fargo 20th Annual Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Wells Fargo 20th Annual Healthcare Conference 2025 summary4 Sep, 2025
Company overview and growth trajectory
Focused on value creation with a commercialized product, Arclis, showing strong revenue growth since its 2021 launch, reaching $156.8M in Q2 and guiding $625M–$640M for 2025.
Penetration into the target patient population is about 15%, indicating significant room for expansion.
Development pipeline includes KPL-387 (monthly liquid formulation, auto-injector) in Phase II/III, aiming for market entry in 2028–2029, and 1161, a quarterly antibody targeting IL-1 alpha and beta.
Arclis commercialization and market dynamics
Arclis is the first and only FDA-approved therapy for recurrent pericarditis, with a broad label and growing prescriber base (over 3,475 prescribers as of Q2).
Patient education, physician outreach, and digital strategies, including AI, are driving adoption.
Medicare Part D changes led to a one-time patient bolus, with ongoing monitoring of affordability and access.
Average treatment duration is 30 months, with 45% of patients restarting therapy after stopping.
Pipeline development and clinical strategy
KPL-387 targets monthly dosing with strong physician and patient preference; Phase II data expected in 2026, with market entry targeted for 2028–2029.
Phase I data show sustained drug levels and a safety profile consistent with IL-1 inhibition.
1161 is in preclinical development, aiming for quarterly dosing and broader auto-inflammatory indications.
Arclis: How to expand beyond 15% penetration?
KPL-387: How will it expand the RP market?
Pipeline expansion: How to maintain cash flow positive?
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Next Kiniksa Pharmaceuticals International earnings date
Q3 202528 Oct, 2025
Next Kiniksa Pharmaceuticals International earnings date
Q3 202528 Oct, 2025
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Frequently asked questions
Kiniksa Pharmaceuticals International, plc is a commercial-stage biopharmaceutical company focused on discovering, acquiring, developing, and commercializing therapeutic medicines. The company's work targets debilitating diseases with significant unmet medical needs, particularly within cardiovascular and autoimmune disorders. Kiniksa's portfolio includes products and candidates based on strong biological rationale or validated mechanisms, offering potential differentiation in treatment approaches. The company is known for its flagship product, ARCALYST, which is used to treat certain inflammatory cardiovascular conditions. The company is headquarted in London, UK, and its shares are listed on the NASDAQ.
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