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Investor Relations14 Oct 2025
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MeiraGTx Holdings (MGTX) investor relations material
MeiraGTx Holdings Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary14 Aug, 2025
Executive summary
Net loss for Q2 2025 was $38.8M, improved from $48.6M in Q2 2024; six-month net loss was $78.8M versus $69.1M year-over-year.
Service revenue rose to $3.7M in Q2 2025 from $0.3M in Q2 2024, driven by PPQ services under the Johnson & Johnson agreement.
Operating expenses for Q2 2025 were $48.5M, up from $46.2M in Q2 2024; six-month operating expenses were $92.0M, slightly down from $93.7M year-over-year.
Strategic collaboration and joint venture with Hologen/Hologen AI expected to provide $200M upfront, up to $230M additional funding, with $23M received to date.
Achieved key regulatory milestones, including FDA alignment on pivotal Phase 2 studies and RMAT designations for AAV-hAQP1 and AAV-GAD programs.
Financial highlights
Cash, cash equivalents, and restricted cash totaled $34.4M as of June 30, 2025, down from $101.0M a year earlier.
Service revenue for the six months ended June 30, 2025 was $5.6M, up from $1.0M in the prior year period.
Research and development expenses decreased to $33.5M in Q2 2025 from $34.9M in Q2 2024, primarily due to lower manufacturing and program-specific costs.
Foreign currency gain of $8.6M in Q2 2025 versus a $0.3M loss in Q2 2024, driven by USD weakness against GBP and EUR.
Operating loss for Q2 2025 was $44.8M, compared to $45.9M in Q2 2024.
Outlook and guidance
Current cash, receivables, and anticipated Hologen proceeds are expected to fund operations into 2027 and cover $75M debt due August 2026.
Excludes potential $285M in milestones from Johnson & Johnson upon commercial sales and tech transfer milestones.
Ongoing and planned clinical trials for AAV-hAQP1, AAV-GAD, and AAV-AIPL1, with pivotal data readouts and regulatory submissions targeted for late 2026 and 2027.
Plans to initiate first-in-human studies for riboswitch platform and new pain program in 2025.
Assess the impact of Hologen collaboration on AAV-GAD.
Address AAV-hAQP1's potential beyond RIX.
Discuss the implications of riboswitch platform.
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Next MeiraGTx Holdings earnings date
Q3 202514 Nov, 2025
Next MeiraGTx Holdings earnings date
Q3 202514 Nov, 2025
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Frequently asked questions
MeiraGTx Holdings plc is a clinical-stage gene therapy company dedicated to developing potentially curative treatments for patients suffering from serious diseases. The company's research and development efforts are currently concentrated on six clinical programs, which include treatments for four types of ocular diseases, a salivary gland condition, and Parkinson’s disease. MeiraGTx's approach is particularly focused on areas with significant unmet medical needs, such as diseases of the eye, salivary gland, and central nervous system. The company is headquartered in New York and London, and its shares are listed on the Nasdaq.
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