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MeiraGTx Holdings (MGTX) investor relations material
MeiraGTx Holdings Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary13 Nov, 2025
Executive summary
Clinical-stage genetic medicines company with late-stage programs in Parkinson's, xerostomia, and retinal dystrophy, and advanced pivotal Phase 2 and Phase 3 studies.
Internal end-to-end manufacturing capabilities and proprietary gene regulation platform.
Strategic collaborations with Hologen AI and Eli Lilly, including significant upfront and milestone payments, and joint ventures.
Acquisition of Smart Immune assets to expand cell therapy pipeline.
Completed optimization of riboswitch leptin program, with IND-enabling discussions ongoing.
Financial highlights
Net loss of $50.5M for Q3 2025, up from $39.3M in Q3 2024; net loss of $129.3M for nine months ended September 30, 2025.
Revenue of $0.4M for Q3 2025, down from $10.9M in Q3 2024; $6.0M for nine months, down from $11.9M year-over-year.
Cash, cash equivalents, and restricted cash of $17.1M as of September 30, 2025, down from $105.7M at December 31, 2024.
Operating expenses decreased to $46.5M in Q3 2025 from $51.0M in Q3 2024; $138.5M for nine months, down from $144.6M.
R&D expenses increased to $32.5M in Q3 2025 from $26.2M in Q3 2024, mainly due to higher manufacturing and clinical trial material costs.
Outlook and guidance
Anticipates sufficient funding into the second half of 2027, including repayment of $75M debt due August 2026, supported by upfront and milestone payments from Eli Lilly and Hologen AI.
Expects pivotal data for AAV-hAQP1 in early 2027, with potential BLA filing and approval later that year.
Expects continued operating losses and need for additional capital for product development and commercialization.
Plans to initiate Phase 3 AAV-GAD study for Parkinson's disease in the coming months.
Riboswitch leptin program expected to enter the clinic following IND-enabling discussions.
What technologies did Lilly license for ophthalmology?
How will the $75M debt due Aug 2026 be repaid?
Hologen AI's role in manufacturing optimization
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Next MeiraGTx Holdings earnings date
Q4 202513 Mar, 2026
Next MeiraGTx Holdings earnings date
Q4 202513 Mar, 2026
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Frequently asked questions
MeiraGTx Holdings plc is a clinical-stage gene therapy company dedicated to developing potentially curative treatments for patients suffering from serious diseases. The company's research and development efforts are currently concentrated on six clinical programs, which include treatments for four types of ocular diseases, a salivary gland condition, and Parkinson’s disease. MeiraGTx's approach is particularly focused on areas with significant unmet medical needs, such as diseases of the eye, salivary gland, and central nervous system. The company is headquartered in New York and London, and its shares are listed on the Nasdaq.
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