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Natera (NTRA) investor relations material

Natera 44th Annual J.P. Morgan Healthcare Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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44th Annual J.P. Morgan Healthcare Conference summary14 Jan, 2026

Corporate strategy, technology innovation, and market positioning

  • Focused on transforming disease management globally with proprietary cell-free DNA detection technology, targeting large, underpenetrated markets in women's health, organ health, and oncology.

  • Over 16 million tests processed since 2013, with a broad portfolio in oncology, women's health, and organ health.

  • Achieved market leadership in cell-free DNA testing, with over 50% share in women's health, supported by more than 350 peer-reviewed publications and 600+ issued or pending patents.

  • Emphasis on innovation, clinical validation, and customer experience as key success drivers.

  • Integrated AI and foundation models for augmented MRD scoring and digital pathology, partnering with NVIDIA and Ultima Genomics.

Financial performance and growth

  • Record year in 2025 with 924,000 units in Q4, driven by strong growth in all segments and record test volumes for Signatera and Fetal Focus.

  • Q4 2025 revenues up 39% year-over-year, reaching $660 million, with over $100 million in free cash flow.

  • Clinical MRD volumes reached a record, with fastest unit growth at 22,800 in Q4 2025 and acceleration across multiple tumor types.

  • Continued ASP growth expected in 2026, supported by expanded Medicare coverage and biomarker laws.

  • Operating expenses to grow ~10% in 2026, mainly in R&D, with profitability expected as revenue matures.

Product innovation and launches

  • Launched Fetal Focus, a 21-gene single-gene NIPT with 96% sensitivity and 98% specificity, validated in the EXPAND trial.

  • Expanded MRD detection portfolio with Signatera on both exome and genome, and introduced tissue-free MRD for CRC and other tumor types.

  • Acquired Foresight Diagnostics, adding ultrasensitive phased variant technology and strengthening MRD capabilities, especially in lymphoma and hematologic cancers.

  • Integrated phased variant technology for pan-cancer MRD applications.

  • Collaborations with NVIDIA and Ultima Genomics to advance AI and sequencing capabilities.

Foresight: tech integration & lymphoma market entry
What makes Natera's AI-MRD model unique?
Pharma leveraging Natera's commercial MRD for trials
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Q4 202527 Feb, 2026
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Frequently asked questions

Natera, Inc. develops and commercializes molecular testing services for reproductive health. It provides Panorama, a non-invasive prenatal test that screens for chromosomal abnormalities of a fetus with a blood draw from the mother; Vistara, a single-gene mutations screening test to analyze chromosomal anomalies or subchromosomal aberrations; Horizon carrier screening to determine carrier status for various genetic diseases that could be passed on to the carrier's children; Spectrum pre-implantation genetic screening and Spectrum pre-implantation genetic diagnosis to analyze chromosomal anomalies or subchromosomal aberrations; and Anora product platform, a single tube platform to detect cell-free DNA in maternal blood.

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