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Novavax (NVAX) investor relations material
Novavax Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Strategic transformation and partnerships
Transitioning from pandemic response to an endemic-focused vaccine manufacturer, emphasizing a leaner cost structure and diversified revenue streams.
Major partnership with Sanofi enables commercialization of COVID-19 vaccine, development of combination vaccines, and integration of Matrix-M adjuvant into Sanofi’s portfolio.
Sanofi agreement includes $70M investment, $500M upfront, and up to $700M in milestones, with significant royalties on both COVID and combination vaccines.
Matrix-M adjuvant licensed non-exclusively, allowing for additional deals and innovation across the vaccine industry.
Ongoing cost reduction and balance sheet strengthening to drive future profitability.
Commercialization and market outlook
2025 is a transition year for Sanofi’s commercialization of the COVID-19 vaccine, focusing on learning and limited marketing, with a full launch planned for 2026.
Sanofi’s combination flu and COVID-19 vaccines have received positive early data and fast track designation from the FDA.
The combination vaccine market could reach $8B annually, with high-value milestones and royalties expected.
BARDA agreement for H5N1 pandemic flu vaccine with Matrix-M highlights strategic importance for global health security.
Matrix-M royalties extend up to 20 years for new Sanofi vaccines, with up to $200M in milestones per product.
Innovation and pipeline development
Matrix-M is positioned as a platform technology, with two top 10 pharma companies and an oncology partner evaluating it under master agreements.
Scientific data shows Matrix-M enables balanced immune responses, supporting its use in infectious disease and oncology vaccines.
AI and machine learning are used to optimize Matrix-M formulations for tailored immune responses.
Oncology vaccine collaboration is underway, with updates expected in coming quarters.
Matrix-M’s non-exclusive model is designed to foster broad industry innovation, not just internal development.
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