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OPKO Health
OPKO Health (OPK) investor relations material
OPKO Health 44th Annual J.P. Morgan Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.44th Annual J.P. Morgan Healthcare Conference summary14 Jan, 2026
Business overview and strategic direction
Focus shifted toward therapeutics, divesting 40% of clinical diagnostics to improve profitability and rebalance the balance sheet.
Remaining diagnostics business is now break-even and profitable, centered in New York and New Jersey, with cancer diagnostics as a key area.
ModeX Therapeutics, acquired in 2022, drives biotech innovation with multi-specific antibody and vaccine platforms.
Strategic partnerships with Merck, Regeneron, and BARDA provide non-dilutive financing and expand the pipeline.
International pharmaceutical and Rayaldee product lines are performing well, contributing to financial stability.
Financial performance and guidance
Clinical lab business restructured for profitability, focusing on high-margin tests like 4Kscore, which grew over 15% in testing volume.
Revenue growth for diagnostics projected at 3%-5% in 2026, with a $300 million base and single-digit EBITDA targeted.
Cash flow positive operations expected by end of 2026.
Over $100 million returned to shareholders in 2024; further guidance on stock buyback to be provided in February 2025.
Key pipeline and partnership updates
Merck-partnered EBV vaccine completed phase 1; phase 2 decision expected in Q1, with significant financial milestones tied to progression.
MDX-2001 (solid tumor T-cell engager) nearing phase 1A completion, with phase 1B to focus on responsive tumor types and further safety/efficacy data.
MDX-2004, a first-in-class trispecific antibody, is in early clinical trials targeting immune rejuvenation, with broad potential applications.
BARDA supports anti-COVID and pan-flu antibody programs, with phase 1 entry for COVID and ongoing FDA engagement for flu.
Regeneron partnership targets four programs in obesity, metabolism, cancer, and immunology, with up to $1.2 billion in milestones; candidate selection expected by early 2026.
Impact of DRE removal on 4Kscore adoption?
MDX2004: Efficacy in PD-1 failed patients?
Preclinical evidence for Regeneron candidates?
Partial view of Summaries dataset, powered by Quartr API
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Next OPKO Health earnings date
Q4 202527 Feb, 2026
OPKO Health
Next OPKO Health earnings date
Q4 202527 Feb, 2026
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Frequently asked questions
OPKO Health, Inc., together with its subsidiaries, provides diagnostic and pharmaceutical products to patients in the United States and internationally. The company offers clinical laboratory diagnostic services under the Diagnostic Systems Laboratories (DSL) brand name. It also develops and commercializes pharmaceutical products for oncology, cardiovascular disease, hospital intensive care, gout and metabolic disorders, reproductive health and urology; as well as complementary dietary supplement products for women’s health, eye care and mineral deficiencies. In addition, it engages in the research and development of proprietary medical imaging contrast agents for use in cardiac electrophysiological procedures; along with advanced personalized genetic diagnostics technology using microfluidics extracted from blood samples to help identify genetic markers associated with disease onset or progression; as well as biomarkers associated with efficacy that are useful in assessing treatment options
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