Predictive Oncology (POAI) investor relations material

Executive summary

• Launched a digital asset treasury strategy centered on Aethir's ATH token, establishing the world's first Strategic Compute Reserve to address AI infrastructure needs and generate new revenue streams, with significant balance sheet allocation to ATH holdings and staking activities.

• Strategic partnerships and collaborations, including with Aethir and Every Cure, position the company to benefit from surging global demand for AI compute power and drug repurposing opportunities.

• Discontinued and sold non-core segments, including Eagan and Birmingham, to streamline business and focus on AI-driven oncology drug discovery and digital asset management.

• Closed major private placements in late 2025, raising $50.8 million in cash and receiving ATH tokens valued between $173.3 million (discounted) and $292.7 million (notional), supporting liquidity and the Treasury Strategy.

• Regained Nasdaq compliance after a reverse stock split and capital raise, but remains at risk of future delisting if requirements are not maintained.

Financial highlights

• Ended Q3 2025 with $182,000 in cash and cash equivalents, down from $612,000 at year-end 2024, with subsequent capital raises bolstering liquidity.

• Net loss for Q3 2025 was $77.7 million, compared to $3.1 million in Q3 2024, driven by a $74.4 million non-cash derivative loss related to ATH; net loss for the nine months ended September 30, 2025 was $81.9 million.

• Revenue for Q3 2025 was $3,618, nearly flat year-over-year; revenue for the nine months ended September 30, 2025 was $116,610, up from $76,020, mainly due to a tumor-specific 3D model.

• General and administrative expenses rose to $6.3 million for the nine months, up from $5.7 million, mainly due to legal and stock-based compensation costs.

• Cash flow used for operations was $5.9 million for the nine months ended September 30, 2025, a 26% reduction from $8.0 million in the prior year period.

Outlook and guidance

• Management expects the current cash position, including proceeds from recent private placements, to fund operations for at least 12 months.

• Targeting a high single-digit yield on ATH tokens for fiscal year 2026, leveraging multiple revenue streams including staking, leasing, and token rotation.

• No formal revenue or earnings guidance provided; results may be volatile due to digital asset exposure and ATH performance.

• Immediate priority is to drive baseline cash flow to sustain operations, with a long-term goal of building a profitable, scalable business model.

• Anticipates continued accumulation of ATH tokens and further expansion of digital asset activities.