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Coiled Therapeutics (COIL) investor relations material
Coiled Therapeutics H2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Completed strategic pivot from pre-clinical to clinical-stage oncology, acquiring exclusive worldwide rights to AO-252, a first-in-class TACC3 inhibitor in Phase I trials.
Raised £8.5 million gross via share placing, supporting clinical milestones through 2026–2027.
Relisted on AIM, changed name to Coiled Therapeutics plc, and restructured Board to align with new clinical focus.
Financial highlights
Reported a consolidated loss of £3,362,074 for 2025, up from £971,803 in 2024, mainly due to impairment charges and AO-252 acquisition costs.
Net equity at year-end was £2,419,645 (2024: £4,889,019); closing cash was £78,054 (2024: £337,112).
Administrative expenses decreased to £683,653 (2024: £931,642); R&D spend was £149,529 (2024: £152,915).
Net cash outflow for 2025 was £259,623; net cash from financing activities was £386,001.
Outlook and guidance
Well-funded to reach key AO-252 clinical milestones, with major data readouts expected in H2 2026.
Plans to initiate dose expansion cohorts in ovarian and prostate cancer, targeting 40 patients by Q3 2026.
Strategic focus remains on AO-252, with STAT-6 siRNA programme under review for potential Phase I trials or out-licensing.
- Exclusive rights to AO-252 position the company for major oncology breakthroughs and partnerships.COIL
Corporate presentation20 Mar 2026 - Loss narrowed, asset sales agreed, but funding and going concern risks persist.COIL
H2 202423 Feb 2026 - £30m acquisition delivers clinical-stage assets, AI-driven oncology, and new funding.COIL
M&A Announcement27 Dec 2025 - Shifted to clinical-stage focus, acquiring Coiled Therapeutics and narrowing net loss.COIL
H1 20256 Oct 2025 - US$10M Midkine antibody out-licensing, improved loss, and 12 months' funding secured.COIL
H1 202413 Jun 2025
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