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Sensorion (ALSEN) investor relations material
Sensorion H1 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H1 2025 earnings summary17 Sep, 2025
Executive summary
Expedited enrollment completed for first two cohorts in Phase 1/2 Audiogene trial evaluating SENS-501 gene therapy for OTOF-related congenital deafness, with positive initial safety profile in all six patients treated so far.
Early signs of hearing improvement observed in Patient 3 at minimally effective dose; higher dose data from Cohort 2 being gathered, with Data Monitoring Committee review expected by end of H2 2025.
GJB2-GT gene therapy program advancing toward first Clinical Trial Application (CTA) filing in Q1 2026, supported by regulatory discussions in Q3 2025.
SENS-401 Phase 2a study in Cisplatin-Induced Ototoxicity completed enrollment, with topline data expected by end of H2 2025.
Board strengthened with appointment of Amit Munshi as Chairman and Independent Director, bringing extensive biotech leadership experience.
Financial highlights
Cash and short-term deposits totaled €57.1m as of June 30, 2025, down from €77.0m at December 31, 2024.
R&D expenses increased 2% year-over-year to €15.0m; G&A expenses rose to €4.1m from €3.8m.
Net loss widened to €16.0m for H1 2025, compared to €13.9m in H1 2024.
Operating loss for H1 2025 was €16.8m, compared to €15.1m in H1 2024.
Outlook and guidance
Cash position expected to finance operations into Q3 2026.
Key milestones: SENS-501 Data Monitoring Committee review and SENS-401 topline results in H2 2025; GJB2-GT CTA filing in Q1 2026.
SENS-501 higher dose efficacy vs. Cohort 1?
Does SENS-401 protect at high cisplatin doses?
GJB2-GT regulatory path for diverse indications?
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H2 202513 Mar, 2026
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Frequently asked questions
Sensorion SA is a clinical-stage biotechnology company focused on developing therapeutic solutions for inner ear disorders, particularly targeting hearing loss and balance disorders. The company's research and development efforts span from molecular biology to clinical research, aiming to address unmet medical needs related to inner ear pathologies. Sensorion's work includes developing drug treatments designed to restore, treat, and prevent these conditions, leveraging its expertise in animal pharmacology, toxicology, and clinical studies. The company is headquartered in Montpellier, France, and its shares are listed on the Euronext Paris.
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