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Shield Therapeutics
Shield Therapeutics (STX) investor relations material
Shield Therapeutics Q4 2025 TU earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 TU earnings summary22 Jan, 2026
Executive summary
Achieved cash flow positive status in Q4 2025, driven by strong US ACCRUFeR/ACCRUFERⓇ sales and effective cost management, marking a key milestone toward sustainability.
ACCRUFeR/ACCRUFERⓇ became the number one branded prescription oral iron in the US ID/IDA market, with a highly tolerable proprietary formulation.
Expanded global footprint with launches in Canada and regulatory progress in Korea, China, and pediatric populations.
Focused on expanding market share through direct-to-consumer and physician-targeted marketing, with emphasis on primary care, women's health, and digital outreach.
Actively pursuing a second product to leverage the existing sales force and further diversify the portfolio.
Financial highlights
Total 2025 revenues reached approximately $50 million, with $46 million from US ACCRUFeR/ACCRUFERⓇ sales, representing 56% year-over-year growth.
Nearly 200,000 prescriptions dispensed in 2025, up 33% year-over-year.
Net selling price per prescription increased 21% year-over-year to approximately $223 in 2025; Q4 2025 net selling price was $222.
Q4 2025 US revenues were $13.5 million, with 61,000 prescriptions, including 21% consignment at subsidized prices.
Ended Q4 2025 with $11.6 million in cash and cash equivalents, generating $1 million in net cash (excluding $2 million debt refinancing).
Outlook and guidance
Expect to remain cash flow positive and achieve EBIT/operating profitability for full year 2026, supported by continued ACCRUFeR/ACCRUFERⓇ growth.
Pricing for ACCRUFeR/ACCRUFERⓇ anticipated to fluctuate between $222 and $240 per prescription in 2026.
Targeting continued growth in prescriptions and revenues, with a focus on expanding into additional specialties and launching pediatric and international indications.
Peak US sales target for ACCRUFeR/ACCRUFERⓇ remains at $450 million, with further growth expected from new indications and expanded prescriber base.
Actively seeking to add a late-stage or FDA-approved specialty product to the portfolio.
What drives 2026 operating profit expectation
Why did Q4 net selling price decrease
How much of the $2.3B market is captured
Cash flow positive: How does this enable portfolio diversification
U.S. revenue growth slowing, script growth strong. Why?
Which new market/indication offers biggest upside?
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Latest events from Shield Therapeutics
- 146% revenue growth and improved margins set the stage for cash flow positivity by end of 2025.STX
H2 202425 Feb 2026 - H1 2024 revenues tripled to $12.1M on US growth; break-even targeted for H2 2025.STXH1 202422 Jan 2026
- Prescription growth and new financing support cash flow positivity by end-2025.STXTrading Update17 Jan 2026
- ACCRUFeR sales rose 153% in FY24, driving revenue growth and cash flow progress.STXTrading Update2 Dec 2025
- Q1 2025 revenues surged, March rebounded, and cash flow positivity remains on track.STXTrading Update28 Nov 2025
- Q2 net revenues doubled to $12.8M, with strong prescription growth and cash flow positivity on track.STXTrading Update16 Nov 2025
- Q3 2025 revenues rose 86% YoY to $13.1m, with cash flow positivity targeted for Q4 2025.STXTrading Update23 Oct 2025
- H1 2025 revenue rose 1.8x to $21.4M, losses narrowed, and cash flow positivity is on track.STXH1 202515 Sep 2025
- ACCRUFER® drives strong growth for Shield Therapeutics in the vast iron deficiency market.STXCorporate Presentation13 Jun 2025
Next Shield Therapeutics earnings date
H2 202523 Apr, 2026
Shield Therapeutics
Next Shield Therapeutics earnings date
H2 202523 Apr, 2026
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Frequently asked questions
Shield Therapeutics plc is a specialty pharmaceutical company focused on the development and commercialization of treatments for iron deficiency and related conditions. The company's lead product, Accrufer/Feraccru® (ferric maltol), is an oral iron therapy designed to treat iron deficiency in patients who cannot tolerate traditional iron supplements. Shield Therapeutics operates in Europe and the United States, partnering with healthcare providers and pharmaceutical distributors to expand its market reach. The company is headquartered in Gateshead, United Kingdom, and its shares are listed on the AIM.
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