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Tempest Therapeutics (TPST) investor relations material
Tempest Therapeutics Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary11 Aug, 2025
Executive summary
Clinical-stage biotech focused on cancer therapies, with amezalpat ready for pivotal Phase 3 in liver cancer and TPST-1495 entering Phase 2 for FAP, both with recent regulatory designations and positive trial data.
Cleared to begin pivotal amezalpat trial for first-line HCC in China, expanding on prior US and EU clearances.
Received orphan drug designations for amezalpat (HCC) and TPST-1495 (FAP) from FDA and EMA.
In April 2025, initiated a strategic review to explore alternatives including mergers, acquisitions, or partnerships, and implemented significant cost reductions including a 21-person workforce reduction.
Key executives transitioned to consulting roles; company retained MTS Health Partners to advise on strategic options.
Financial highlights
Cash and cash equivalents were $14.3 million as of June 30, 2025, down from $30.3 million at December 31, 2024.
Net loss for Q2 2025 was $7.9 million ($2.07/share), a decrease from $9.6 million ($5.52/share) in Q2 2024; net loss for the six months ended June 30, 2025 was $18.7 million ($5.17/share), up from $17.5 million ($10.15/share) year-over-year.
Research and development expenses for Q2 2025 were $3.9 million, down 34% year-over-year; general and administrative expenses increased to $4.1 million, mainly due to one-time separation costs.
Operating cash outflows for the first half of 2025 were $16.5 million, compared to $12.7 million in the prior year period.
Raised $4.1 million in a registered direct offering and $2.8 million via ATM program in H1 2025; repaid $3.5 million to fully satisfy outstanding loan.
Outlook and guidance
Existing cash is expected to fund operations for less than 12 months from the date of the financial statements, raising substantial doubt about going concern.
Advancement of amezalpat into Phase 3 and TPST-1495 into Phase 2 is contingent on securing additional resources or a strategic transaction.
Actively pursuing strategic alternatives to advance clinical programs and maximize stockholder value.
Ongoing strategic review may result in mergers, acquisitions, partnerships, or other transactions; no timetable set for completion.
Update on strategic alternatives process
Pivotal trial funding strategy?
Cash runway projection?
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Next Tempest Therapeutics earnings date
Q3 202511 Nov, 2025
Next Tempest Therapeutics earnings date
Q3 202511 Nov, 2025
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Frequently asked questions
Tempest Therapeutics Inc. is a clinical-stage biotechnology firm dedicated to developing small molecule therapeutics aimed at treating cancer. Their approach involves mechanisms that not only directly kill tumor cells but also activate tumor-specific immunity. The company is headquartered in Brisbane, California, and its shares are listed on the NASDAQ.
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