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Tenaya Therapeutics (TNYA) investor relations material

Tenaya Therapeutics Chardan’s 9th Annual Genetic Medicines Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Chardan’s 9th Annual Genetic Medicines Conference summary21 Oct, 2025

Key trends and industry outlook

  • Cardiac gene therapy is advancing with proof-of-concept data, despite some safety setbacks and regulatory scrutiny, but momentum is building due to supportive regulatory commentary and precision medicine trends.

  • The field is seeing a shift toward both rare and prevalent cardiac diseases, with companies leveraging novel capsids, local delivery, and improved manufacturing to address safety, efficacy, and scalability.

  • Regulatory agencies, especially the FDA, are increasingly open to biomarker-based and surrogate endpoints for accelerated approvals, particularly in high unmet need areas.

  • Commercialization is a growing focus, with the need for successful launches, payer engagement, and market uptake now seen as the next major hurdle for gene therapy.

  • The innovation cycle in gene therapy is peaking again, with clinical maturity and new products expected to drive renewed investment and industry growth.

Clinical and technical advances

  • Companies are developing novel AAV capsids and proprietary plasmid systems to improve cardiac cell targeting, reduce required doses, and minimize off-target toxicity.

  • Lead programs target diseases like BAG3 dilated cardiomyopathy, Friedreich’s ataxia, and arrhythmogenic cardiomyopathy, with early clinical and preclinical data showing promising efficacy and safety.

  • Non-invasive imaging, cardiac biomarkers, and functional endpoints are central to trial design, enabling rapid assessment of therapeutic impact and supporting regulatory submissions.

  • Manufacturing improvements, such as higher yields and lower cost of goods, are making large-scale and prevalent disease indications more commercially viable.

  • Local delivery approaches and lower dosing strategies are reducing the need for immunosuppression and improving patient safety profiles.

Commercial and regulatory considerations

  • The field is moving beyond clinical proof to focus on commercial readiness, including manufacturing scale, payer engagement, and precision medicine implementation in cardiology.

  • Advances in genetic testing and the introduction of precision therapies are expected to transform the cardiovascular treatment landscape, mirroring trends in oncology.

  • Regulatory flexibility remains strong, with agencies supporting innovative endpoints and trial designs, especially in rare diseases.

  • Portfolio strategies balance rare and common disease programs, with large partners enabling global trials and broader market access.

  • Industry sentiment is improving, with valuations rebounding and optimism about upcoming clinical readouts and approvals.

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Frequently asked questions

Tenaya Therapeutics Inc. is a biotechnology company focused on discovering, developing, and delivering therapies for heart disease. The company's approach involves multiple therapeutic modalities, including gene therapy, cellular regeneration, and precision medicine, to address both rare genetic and prevalent forms of cardiovascular disease. Tenaya's research aims to target the underlying causes of heart disease, offering potential treatments for conditions that currently have limited therapeutic options. The company is headquartered in South San Francisco, California, and its shares are listed on the Nasdaq.

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