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Theravance Biopharma (TBPH) investor relations material
Theravance Biopharma Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary4 Dec, 2025
Business evolution and financial position
Refocused operations over the past five years, now emphasizing a strong cash position, no debt, and reduced burn rate.
Current priorities include maximizing cash flow from Yupelri and advancing a Phase 3 neuro product, with a key data readout expected in Q1 next year.
Holds $330 million in cash and expects $175 million in near-term milestones within 15 months.
Ampreloxetine and the Cypress study
Ampreloxetine targets neurogenic orthostatic hypotension (nOH) in MSA patients, with prior studies showing a strong efficacy signal in this subgroup.
The Redwood study demonstrated a 1.6-point improvement in the OHSA composite, exceeding the clinically meaningful threshold of one point.
Cypress is designed as an MSA-only pivotal study, closely mirroring Redwood, with a 20-week randomized withdrawal structure and FDA-aligned endpoints.
Over 800 patients have been exposed to ampreloxetine in clinical trials, and most NDA components are complete, awaiting Cypress data.
No increase in supine hypertension observed with ampreloxetine, differentiating it from incumbent treatments.
Commercial and market strategy
Early and ongoing engagement with investigators and payers in the US, Europe, and Asia to support future commercialization.
Initial payer feedback has been positive, with pricing expectations aligned with rare neurological conditions.
A key opinion leader event is scheduled for December to further discuss commercial strategies.
How does ampraloxetine avoid supine hypertension?
Yupelri: Improve hospital-to-home persistence
Yupelri margin expansion timeline
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Next Theravance Biopharma earnings date
Status Update8 Dec, 2025
Next Theravance Biopharma earnings date
Status Update8 Dec, 2025
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Frequently asked questions
Theravance Biopharma Inc. is a biopharmaceutical company that focuses on the discovery, development, and commercialization of respiratory and organ-selective medicines. The company's primary product is YUPELRI (revefenacin), a once-daily nebulized therapy used for the maintenance treatment of chronic obstructive pulmonary disease (COPD). Theravance Biopharma is also involved in the development of Ampreloxetine, an investigational norepinephrine reuptake inhibitor, targeting neurogenic orthostatic hypotension, and has collaborations for additional research in respiratory and immunological disorders. The company is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.
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