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Company Research30 Jun 2025
Eli Lilly: The Pharma Giant Behind Mounjaro and Zepbound
Eli Lilly's journey from insulin pioneer to global pharma giant, leading innovation in diabetes, obesity, and the future of metabolic health.
AbbVie
AbbVie (ABBV) investor relations material
AbbVie Piper Sandler Virtual Novel Targets in Immunology Symposium summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler Virtual Novel Targets in Immunology Symposium summary13 Feb, 2026
Key data readouts and clinical differentiation
Lutikizumab and RINVOQ are being developed for hidradenitis suppurativa (HS), with a focus on clinical differentiation through a mechanistically distinct approach targeting IL-1 alpha and beta.
Lutikizumab's bispecific targeting of IL-1 alpha and beta is seen as crucial due to their synergistic roles in HS pathology.
Phase II data for lutikizumab show strong efficacy in both biologic-experienced and naive HS patients, with differentiated results.
Double-blind week 16 data for both lutikizumab and RINVOQ in HS are expected by year-end.
Conventional wisdom suggests higher efficacy in biologic-naive patients, but lutikizumab has shown meaningful effects even in TNF-failure populations.
Competitive landscape and development strategy
The HS development landscape includes IL-1 beta-specific agents and OX40 TNF-directed bispecifics, with safety and immunogenicity challenges noted for some competitors.
Targeting both IL-1 alpha and beta is considered superior to beta alone, potentially blocking compensatory mechanisms and providing synergistic effects.
Anti-TNF bispecifics face immunogenicity issues, prompting a shift toward novel mechanisms.
IBD pipeline and combination approaches
Multiple combination studies are ongoing in IBD, including SKYRIZI with lutikizumab, TL1A-directed treatments, and alpha-4 beta-7 agents.
Subcutaneous SKYRIZI data are expected this year, potentially enhancing market position.
Alpha-4 beta-7 and TL1A combinations are prioritized, with phase transitions anticipated soon.
TREM1, a novel mechanism, is being evaluated as monotherapy, with potential for future combinations.
Ludy's IL-1 alpha/beta role in HS differentiation
Why IBD combos to break efficacy ceiling?
TL1A's broader fibrotic disease development
Partial view of Summaries dataset, powered by Quartr API
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Next AbbVie earnings date
Q1 202624 Apr, 2026
AbbVie
Next AbbVie earnings date
Q1 202624 Apr, 2026
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Frequently asked questions
Innovative therapies for improved health worldwide
Abbvie is a global biopharmaceutical company that focuses on the discovery, development, and commercialization of innovative medicines. The company's mission is to address complex health challenges and improve the lives of people around the world. Abbvie's primary areas of therapeutic focus include immunology, oncology, neuroscience, virology, and general medicine.
Abbvie's business model revolves around research and development (R&D) to discover and advance novel therapies, obtaining regulatory approvals for its products, and commercializing them in global markets. The company's revenue primarily comes from the sales of its pharmaceutical products.
Structural tailwinds
Opportunities for Abbvie lie in several areas. The global healthcare market continues to grow as the population ages, and there is a constant need for effective treatments for various diseases. Abbvie can leverage its R&D capabilities to develop innovative therapies that address unmet medical needs, expanding its product portfolio and capturing market share.
Furthermore, Abbvie has a robust pipeline of potential new drugs, which presents opportunities for future growth. By successfully developing and commercializing these pipeline candidates, the company can strengthen its market position and drive revenue growth.
Challenges faced by Abbvie include the competitive nature of the pharmaceutical industry. There are other established pharmaceutical companies and biotech firms developing treatments for similar indications. Abbvie needs to navigate patent expirations, competition from generic drugs, and the potential impact of biosimilars on its revenue.
Additionally, the regulatory environment poses challenges for Abbvie. Obtaining regulatory approvals for new drugs is a complex and time-consuming process, and the company must meet stringent safety and efficacy requirements set by regulatory authorities worldwide.
Three listed peers to Abbvie
Johnson & Johnson, a multinational healthcare conglomerate that operates in various segments, including pharmaceuticals, medical devices, and consumer health. It develops and sells a wide range of products and therapies across multiple therapeutic areas.
The leading global pharmaceutical company Pfizer that develops, manufactures, and markets a diverse portfolio of prescription drugs, vaccines, and consumer healthcare products. It has a strong presence in various therapeutic areas, including oncology, immunology, and rare diseases.
Eli Lilly and Company, a global pharmaceutical company that focuses on developing and commercializing innovative medicines in areas such as oncology, diabetes, neuroscience, and immunology. The company is known for its expertise in biotechnology and has a strong pipeline of potential new drugs.
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